High-dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura
| Autor: | Gülersu Irken, Adnan Karabent, Ş. Özsoylu |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Administration Oral Cushingoid Gastroenterology Methylprednisolone Prednisone Internal medicine medicine Humans Platelet Child Chemotherapy business.industry Platelet Count Remission Induction Infant Hematology General Medicine medicine.disease Thrombocytopenic purpura Surgery Purpura Purpura Thrombocytopenic Child Preschool Acute Disease Injections Intravenous Corticosteroid Female medicine.symptom business medicine.drug Follow-Up Studies |
| Zdroj: | European journal of haematology. 42(5) |
| ISSN: | 0902-4441 |
| Popis: | 49 children with acute idiopathic thrombocytopenic purpura (ITP) were divided into non-treatment, oral prednisone (2 mg/kg), and high-dose intravenous methylprednisolone (HIVMP) treatment groups which consisted of 17, 16 and 16 children respectively. Platelet counts rose above 150,000/microliters over a 2-week period in 5 (29.4%) children in the first group, 5 (31.2%) in the second group and 15 (93.7%) children in the third group. Platelet counts reached the normal level in only 3 days in 11 (68.7%) children treated with HIVMP. Initially, antiplatelet antibodies (APA) were shown by the Handin and Stossel method in every patient. With normalization of platelet counts, the antibodies decreased but could still be detected in every case; antibody decrease was greater in the HIVMP group. With the exception of mild cushingoid appearance, none of the major corticosteroid side effects was observed in the treated children. |
| Databáze: | OpenAIRE |
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