The effect of atorvastatin on haemostatic parameters in apparently healthy dogs
Autor: | J. E. Patlogar, M. Wiebe, H. E. Espinoza, A. Bonaparte, L. A. Murphy, C. Tansey, R. K. Nakamura |
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Rok vydání: | 2019 |
Předmět: |
040301 veterinary sciences
Atorvastatin Fibrinogen Hemostatics 0403 veterinary science Dogs medicine Animals Thromboplastin Dog Diseases Prospective Studies Small Animals Mean corpuscular volume Prothrombin time medicine.diagnostic_test business.industry 0402 animal and dairy science Complete blood count 04 agricultural and veterinary sciences 040201 dairy & animal science Thromboelastography Thrombelastography Anesthesia Prothrombin Time business medicine.drug Partial thromboplastin time |
Zdroj: | Journal of Small Animal Practice. 60:565-570 |
ISSN: | 1748-5827 0022-4510 |
Popis: | Objective To determine the effect of atorvastatin on haemostatic parameters as measured by prothrombin time, activated partial thromboplastin time and thromboelastography in apparently healthy dogs administered 2 mg/kg orally once daily for 1 week. Materials and methods Prospective study of 20 apparently healthy client-owned dogs at a small animal specialty hospital. Dogs had a baseline complete blood count, serum chemistry profile, fibrinogen, platelet count, prothrombin time, activated partial thromboplastin time and thromboelastography performed. Each dog was then administered approximately 2 mg/kg of atorvastatin orally once daily for 1 week, and the laboratory tests were repeated. Adverse effects attributed to atorvastatin were recorded. Results All 20 enrolled dogs completed the study. Dogs received a median dose of 2.06 mg/kg (range 1.94 to 2.44 mg/kg) atorvastatin once daily, which was associated with a significant increase in pulse rate, mean corpuscular haemoglobin concentration, albumin and a significant decrease in mean corpuscular volume, cholesterol and lipase values compared with baseline. On thromboelastography, there was a significant increase in maximum amplitude, G, coagulation index, amplitude at 30 minutes, amplitude at 60 minutes and significant decrease in percentage of clot lysed at 30 minutes and percentage of clot lysed at 60 minutes values compared with baseline. Six dogs had a noticeable increase in appetite. Clinical significance The results of this study suggest that atorvastatin may produce a procoagulant effect in dogs, although the clinical significance is unclear. Polyphagia was the most commonly reported adverse effect. |
Databáze: | OpenAIRE |
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