Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats
| Autor: | K. H. L. Schellekens, C. J. E. Niemegeers, Theo F. Meert, P. A. J. Janssen, Frans Awouters |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Drug
Male Substance-Related Disorders media_common.quotation_subject Drinking Alcohol Ritanserin Pharmacology Fentanyl chemistry.chemical_compound Cocaine medicine Animals Pharmacology (medical) media_common Ethanol business.industry Antagonist Rats Inbred Strains General Medicine medicine.disease Rats Substance abuse Psychiatry and Mental health chemistry Anesthesia Serotonin business medicine.drug |
| Zdroj: | Pharmacopsychiatry. 24(5) |
| ISSN: | 0176-3679 |
| Popis: | Rats that had received 3% alcohol, 0.01% cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT2 antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs. |
| Databáze: | OpenAIRE |
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