Molecular Epidemiology and Clinical Manifestations of Adenovirus Respiratory Infections in Taiwanese Children
| Autor: | Pin Hwa Kuo, Fan Ching Shen, Ya Fang Wang, Shan Li Wang, Jen Ren Wang, Huey Pin Tsai, Chia Yu Chi, Ching Chuan Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Genotype 030106 microbiology Taiwan Observational Study Adenovirus Infections Human 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Humans 030212 general & internal medicine Respiratory system Respiratory Tract Infections Retrospective Studies Molecular epidemiology Respiratory tract infections business.industry Coinfection Incidence (epidemiology) Adenoviruses Human Incidence Age Factors Outbreak virus diseases Infant Retrospective cohort study General Medicine medicine.disease Virology eye diseases Hospitalization Pneumonia Child Preschool Female business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Human adenoviruses (HAdVs) are important causes of respiratory infections in children. They usually cause mild upper respiratory symptoms, but they can also produce severe pneumonia and other complications. The aims of this retrospective study were to better define the molecular epidemiology of respiratory adenoviruses circulating in Taiwanese children during 2002 and 2013, detect reinfections and co-infections, and characterize the clinical features and laboratory findings according to the causative genotypes. We collected a representative sample of 182 isolates of adenoviruses from 175 children during the 12-year study period. The most prevalent species was HAdV-B genotype 3 (HAdV-3) (92/182, 50.5%) followed by HAdV-C (HAdV-2) (38/182, 20.9%). A single outbreak of HAdV-E (6/182, 3.3%) was noted in 2007. The mean age of children with adenovirus infections was 3.7 ± 2.0 years, with a slight predominance of males (53.1%). Children with HAdV-B tended to be older, had more lower respiratory tract infections, gastrointestinal symptoms, and a higher rate of hospitalization than those with HAdV-C (P |
| Databáze: | OpenAIRE |
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