Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future
| Autor: | Mohammad Sholeh, Ebrahim Kouhsari, Taghi Amiriani, Nourkhoda Sadeghifard, Mehrdad Gholami, Milad Abdi, Arezoo Asadi, Alireza Ahmadi, Abbas Maleki, Pegah Panahi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Clinical effectiveness 030106 microbiology Immunology Mechanisms of minocycline resistance Minocycline Pharmacology Microbiology Minocycline clinical effectiveness 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Minocycline antibacterial activity Acne Vulgaris medicine Immunology and Allergy Humans 030212 general & internal medicine Acne Mechanism (biology) business.industry medicine.disease Antimicrobial QR1-502 Anti-Bacterial Agents Minocycline resistance Mechanism of action Rheumatoid arthritis medicine.symptom business Antibacterial activity Gram-Negative Bacterial Infections medicine.drug |
| Zdroj: | Journal of Global Antimicrobial Resistance, Vol 22, Iss, Pp 161-174 (2020) |
| ISSN: | 2213-7165 |
| Popis: | Objectives The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-resistant microorganisms leads to appealing therapeutic options. Methods During the last 30 years, minocycline, a wide-spectrum antimicrobial agent, has been effective against MDR Gram-positive and Gram-negative bacterial infections. As with other tetracyclines, the mechanism of action of minocycline involves attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis. Results This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been published, there remains limited information regarding the prevalence, mechanism of resistance and clinical effectiveness of minocycline. Conclusion Thus, we summarize here the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity and clinical effectiveness of minocycline. |
| Databáze: | OpenAIRE |
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