Usefulness of Gd-EOB-DTPA-enhanced MRI for evaluating the potential for early development of hepatocellular carcinoma after HCV eradication by direct-acting antiviral treatment
| Autor: | Rie Goka, Hiroaki Nomoto, Naoki Kunitomo, Norio Isoda, Kouichi Miura, Shunji Watanabe, Hiroyasu Nakamura, Hironori Yamamoto, Kozue Murayama, Yoshinari Takaoka, Takuya Hirosawa, Mamiko Tsukui, Naoki Morimoto, Hideharu Sugimoto |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Hepatitis C virus Gd-EOB-DTPA medicine.disease_cause Gastroenterology sustained virologic response (SVR) hepatocellular carcinoma (HCC) 03 medical and health sciences 0302 clinical medicine Internal medicine medicine In patient 030212 general & internal medicine Antiviral treatment 030222 orthopedics hypo-intense nodule medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease digestive system diseases Hepatocellular carcinoma Original Article business Direct acting MRI |
| Zdroj: | Journal of Rural Medicine : JRM |
| ISSN: | 1880-4888 1880-487X |
| Popis: | Objective: The development of hepatocellular carcinoma (HCC) is not uncommon in patients who achieve eradication of the hepatitis C virus through direct-acting antiviral (DAA) treatment. The aim of this study was to identify the patients at high risk for novel HCC development after a sustained virologic response (SVR) by DAA treatment. Patients and Methods: A total of 518 patients with no history of HCC treatment and who achieved SVR by DAA treatment were evaluated retrospectively. The correlations between HCC development and the patients’ characteristics were evaluated. For patients who underwent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) or dynamic contrast-enhanced computed tomography, the relationship between the imaging findings and subsequent HCC development was also assessed. Results: HCC developed newly in 22 patients, and the 1-year and 3-year cumulative HCC rates were 2.0% and 8.5%, respectively. In multivariate analysis, a FIB-4 index >4.0 and a post-treatment α-fetoprotein >4.0 ng/ml were significant risk factors for HCC. In 26 of 118 patients who underwent an MRI before DAA treatment, a non-hypervascular hypo-intense nodule was seen in the hepatobiliary phase, and in 6 of 182 patients who underwent a CT, a non-hypervascular hypo-enhanced nodule was seen in the delayed phase. The sensitivity and specificity of the MRI-positive findings for the subsequent development of HCC were 0.92 and 0.87, respectively, and those of the CT were 0.40 and 0.99, respectively. In multivariate analysis of patients who underwent an MRI, a non-hypervascular hypo-intense nodule was the only factor that was significantly related to HCC development (HR 32.4, p = 0.001). Conclusion: Gd-EOB-DTPA-enhanced MRI was found to be reliable for risk evaluation of subsequent HCC development in patients after SVR by DAA treatment. Patients with a non-hypervascular hypo-intense nodule need more careful observation for incident HCC. |
| Databáze: | OpenAIRE |
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