CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?
| Autor: | Clement Adebamowo, John Kwagyan, Rick A. Kittles, Aaron G. Jackson, Chiledum Ahaghotu, Robin Griffin, Weidong Chen, Lucile L. Adams-Campbell, William B. Isaacs, Ramesh K. Panguluri, Georgia M. Dunston, Vincent L. Freeman, Flora Ukoli, Tyisha Williams |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Genetic Markers Male Population Black People Nigeria Biology Population stratification White People Mixed Function Oxygenases Prostate cancer Cytochrome P-450 Enzyme System Gene Frequency Genetics medicine Cytochrome P-450 CYP3A Humans Promoter Regions Genetic education Allele frequency Alleles Genetics (clinical) Aged Genetic association Aged 80 and over education.field_of_study Base Sequence Nigerians Confounding Case-control study Genetic Variation Prostatic Neoplasms DNA Neoplasm Middle Aged medicine.disease United States Case-Control Studies Demography |
| Zdroj: | Human Genetics. 110:553-560 |
| ISSN: | 1432-1203 0340-6717 |
| Popis: | CYP3A4-V, an A to G promoter variant associated with prostate cancer in African Americans, exhibits large differences in allele frequency between populations. Given that the African American population is genetically heterogeneous because of its African ancestry and subsequent admixture with European Americans, case-control studies with African Americans are highly susceptible to spurious associations. To test for association with prostate cancer, we genotyped CYP3A4-V in 1376 (2 N) chromosomes from prostate cancer patients and age- and ethnicity-matched controls representing African Americans, Nigerians, and European Americans. To detect population stratification among the African American samples, 10 unlinked genetic markers were genotyped. To correct for the stratification, the uncorrected association statistic was divided by the average of association statistics across the 10 unlinked markers. Sharp differences in CYP3A4-V frequencies were observed between Nigerian and European American controls (0.87 and 0.10, respectively; P |
| Databáze: | OpenAIRE |
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