Extra-hepatic manifestations of autochthonous hepatitis E infection

Autor:	Joanne Palmer, J.G. Hunter, L. McElhinney, Harry R. Dalton, A. Forbes, K.L. Woolson, U. Warshow, Richard P. Bendall, Brendan McLean, Vasilis Panayi, L. Beynon, A. Kotecha, H. C. Dalton, L. Vine, Hyder Hussaini, L. Mihailescu, Richie G. Madden, T. Glasgow, Becky Haywood
Rok vydání:	2014
Předmět:	Adult Male medicine.medical_specialty Lymphocytosis Adolescent Genotype Molecular Sequence Data Comorbidity medicine.disease_cause Gastroenterology Young Adult Hepatitis E virus Internal medicine medicine Humans Pharmacology (medical) Aged Retrospective Studies Aged 80 and over Hepatology business.industry Zoonosis Middle Aged medicine.disease Hepatitis E Hematologic Diseases Surgery Peripheral neuropathy England Cohort Transaminitis Plasmacytoma Female medicine.symptom Nervous System Diseases Symptom Assessment business
Zdroj:	Alimentary pharmacologytherapeutics. 40(11-12)
ISSN:	1365-2036
Popis:	SummaryBackground Autochthonous (locally acquired) hepatitis E is increasingly recognised in developed countries, and is thought to be a porcine zoonosis. A range of extra-hepatic manifestations of hepatitis E infection have been described, but have never been systematically studied. Aim To report the extra-hepatic manifestations of hepatitis E virus. Methods Retrospective review of data of 106 cases of autochthonous hepatitis E (acute n = 105, chronic n = 1). Results Eight (7.5%) cases presented with neurological syndromes, which included brachial neuritis, Guillain-Barre syndrome, peripheral neuropathy, neuromyopathy and vestibular neuritis. Patients with neurological syndromes were younger (median age 40 years, range 34–92 years, P = 0.048) and had a more modest transaminitis (median ALT 471 IU/L, P = 0.015) compared to cases without neurological symptoms [median age 64 years (range 18–88 years), median ALT 1135 IU/L]. One patient presented with a cardiac arrhythmia,twelve patients (11.3%) presented with thrombocytopenia, fourteen (13.2%) with lymphocytosis and eight (7.5%) with a lymphopenia, none of which had any clinical consequence. Serum electrophoresis was performed in 65 patients at presentation, of whom 17 (26%) had a monoclonal gammopathy of uncertain significance. Two cases developed haematological malignancies, acute myeloid leukaemia and duodenal plasmacytoma, 18 and 36 months after presenting with acute hepatitis E infection. Conclusions A range of extra-hepatic manifestations can occur with hepatitis E. Neurological and haematological features of hepatitis E infection are relatively frequent in this UK cohort, and result in significant morbidity which warrants further study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fddd01e3300a507e4ee6ea7c143931 https://pubmed.ncbi.nlm.nih.gov/25881927 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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