Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD
| Autor: | Klaus-Peter Lesch, Brigitte Schmidt, Alexandra Gessner, Heike Weber, Sarah Kittel-Schneider, Susanne Hempel, Andreas Reif, Juliane Kopf, Andrea Meyer, Julia Volkert, Carolin Leistner, Martin Reuß |
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| Přispěvatelé: | Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Nitric Oxide Synthase Type III Metabolite NOS1 Nitric Oxide Synthase Type I Polymorphism Single Nucleotide Nitric oxide Young Adult chemistry.chemical_compound Internal medicine medicine Humans Attention deficit hyperactivity disorder genetic polymorphism Pharmacology (medical) Bipolar disorder Pharmacology Genetics bipolar disorder biology Haplotype biomarkers attention deficit-hyperactivity disorder Middle Aged medicine.disease Nitric oxide synthase Psychiatry and Mental health Endocrinology Real-time polymerase chain reaction Haplotypes chemistry Attention Deficit Disorder with Hyperactivity biology.protein Female |
| Zdroj: | Journal of Psychopharmacology, 29(1), 31-38. SAGE Publications Ltd |
| ISSN: | 0269-8811 |
| Popis: | Introduction: Several studies have shown altered levels of nitric oxide (NO) and its stable metabolites (NOx-) in blood and cerebrospinal fluid of psychiatric patients. The aim of our study was to replicate previous findings and investigate the influence of the nitrinergic system in bipolar disorder and adult attention-deficit/hyperactivity disorder (aADHD) in particular. Methods: The concentrations of NO2- and NO3- in peripheral blood in a sample of aADHD, bipolar disorder (BPD) and controls were analysed. The sample was genotyped for a three marker haplotype in the NOS3 gene (rs2070744, rs1799983 and Intron 4 VNTR) and for genetic variants of the NOS1 gene ( NOS1 ex 1c, NOS1 ex 1f). Finally, qRT PCR was performed. Results: We found significantly lower NOx- levels in BPD ( px- levels ( p=0.05). Conclusion: We could replicate and extend previous findings showing altered NOx- levels in BPD and an influence of NOS3 rs2070744 on NOS3 expression and NOx- concentration. Together, these data point to a role of the nitrinergic pathway in BPD. |
| Databáze: | OpenAIRE |
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