Chikungunya Outbreak in the Republic of the Congo, 2019-Epidemiological, Virological and Entomological Findings of a South-North Multidisciplinary Taskforce Investigation
| Autor: | Fabrizio Carletti, Martina Rueca, Martin Parfait Aimè Coussoud-Mavoungou, Francesca Colavita, Maria Rosaria Capobianchi, Chiara Montaldo, Emanuela Giombini, Richard Kock, Najmul Haider, Cesare Ernesto Maria Gruber, Antonino Di Caro, Jacqueline Lydia Mikolo, Beatriz Escudero-Pérez, Concetta Castilletti, Vincent J. Munster, Stephanie N. Seifert, Biez Ulrich Judicaël, Emily V Nelson, Leonard E. G. Mboera, César Muñoz-Fontela, Vincenzo Puro, Robert J. Fischer, Francesco Vairo, Patrick K. Tungu, Francesco Messina, Francine Ntoumi, Emanuele Nicastri, Lambert Kitembo, Steve Diafouka-Diatela, Marco Iannetta, Barbara Bartolini, Giuseppe Ippolito, Alimuddin Zumla, Chantal Portella, Sergio Gómez-Medina, Simone Lanini |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male chikungunya Republic of Congo lcsh:QR1-502 medicine.disease_cause lcsh:Microbiology Disease Outbreaks 0302 clinical medicine Aedes Chikungunya Aedes spp Child Phylogeny Phylogenetic tree virus diseases Middle Aged Infectious Diseases Congo Child Preschool Larva Enzootic Sylvatic cycle Female Chikungunya virus Adult Adolescent 030231 tropical medicine mosquito Mosquito Vectors Biology Arbovirus Article 03 medical and health sciences Young Adult Virology medicine Animals Humans outbreak Outbreak Bayes Theorem medicine.disease biology.organism_classification Settore MED/17 030104 developmental biology arbovirus Vector (epidemiology) Mutation Chikungunya Fever ONE-HEALTH |
| Zdroj: | Viruses Volume 12 Issue 9 Viruses, Vol 12, Iss 1020, p 1020 (2020) |
| ISSN: | 1999-4915 |
| Popis: | The Republic of Congo (RoC) declared a chikungunya (CHIK) outbreak on 9 February 2019. We conducted a ONE-Human-Animal HEALTH epidemiological, virological and entomological investigation. Methods: We collected national surveillance and epidemiological data. CHIK diagnosis was based on RT-PCR and CHIKV-specific antibodies. Full CHIKV genome sequences were obtained by Sanger and MinION approaches and Bayesian tree phylogenetic analysis was performed. Mosquito larvae and 215 adult mosquitoes were collected in different villages of Kouilou and Pointe-Noire districts and estimates of Aedes (Ae.) mosquitos’ CHIKV-infectious bites obtained. We found two new CHIKV sequences of the East/Central/South African (ECSA) lineage, clustering with the recent enzootic sub-clade 2, showing the A226V mutation. The RoC 2019 CHIKV strain has two novel mutations, E2-T126M and E2-H351N. Phylogenetic suggests a common origin from 2016 Angola strain, from which it diverged around 1989 (95% HPD 1985–1994). The infectious bite pattern was similar for 2017, 2018 and early 2019. One Ae. albopictus pool was RT-PCR positive. The 2019 RoC CHIKV strain seems to be recently introduced or be endemic in sylvatic cycle. Distinct from the contemporary Indian CHIKV isolates and in contrast to the original Central-African strains (transmitted by Ae. aegypti), it carries the A226V mutation, indicating an independent adaptive mutation in response to vector replacement (Ae. albopictus vs Ae. aegypti). |
| Databáze: | OpenAIRE |
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