Intestinal Organoids as a Tool for Inflammatory Bowel Disease Research
| Autor: | A. Grant Butt, Roslyn A. Kemp, Hamish C. K. Angus, Michael Schultz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
organoid Cell T cells Context (language use) Disease Review Bioinformatics Inflammatory bowel disease immunology 03 medical and health sciences 0302 clinical medicine Immune system medicine Organoid diagnostics lcsh:R5-920 business.industry Inflammatory Bowel Disease Intestinal organoids regulation General Medicine medicine.disease digestive system diseases cytokines 030104 developmental biology medicine.anatomical_structure T cell subset Medicine 030211 gastroenterology & hepatology business lcsh:Medicine (General) |
| Zdroj: | Frontiers in Medicine, Vol 6 (2020) Frontiers in Medicine |
| DOI: | 10.3389/fmed.2019.00334/full |
| Popis: | Inflammatory bowel diseases (IBD) are difficult to model as freshly acquired tissues are short-lived, provide data as a snapshot-in-time, and are not always accessible. Many patients with IBD are non-responders to first-line treatments, and responders are prone to developing resistance to treatment over time – resulting in reduced patient quality of life, increased time to remission, and potential relapse. IBDs are heterogenous and we are yet to fully understand the mechanisms of disease; thus, our ability to diagnose and prescribe optimal treatment remains ineffective. Intestinal organoids are derived from patient tissues expanded in vitro. Organoids offer unique insight into individual patient disease and are a potential route to personalized treatments. However, organoid models do not contain functional microbial and immune cell components. In this review, we discuss immune cell subsets in the context of IBD, and the requirement of immune cell and microbial components in organoid models for IBD research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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