Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

Autor:	Hua Huang, Yichen Tan, Carl A. Denard, Mark J. Bartlett, Huimin Zhao, John F. Hartwig, Lu Lu
Rok vydání:	2013
Předmět:	Molecular Structure Tandem Chemistry General Medicine General Chemistry Alkenes Metathesis Catalysis Enzyme catalysis Cytochrome P-450 Enzyme System Organometallic Compounds Epoxy Compounds Organic chemistry
Zdroj:	Angewandte Chemie International Edition. 53:465-469
ISSN:	1433-7851
DOI:	10.1002/anie.201305778
Popis:	Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create products, which cannot be generated with either catalyst alone or in comparable yields by sequential reactions of the two catalysts, have not been reported. Such reactions are challenging to achieve, in part because the milieu in which these catalysts operate are typically different. Herein, two classes of catalysts are demonstrated to react cooperatively in the same system. Combination of a metathesis catalyst and a P450 enzyme lead to a dynamic equilibration of alkenes and a selective epoxidation of the cross-metathesis products. These results show the potential of combining the two classes of catalysts for synthetic transformations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f6d38afa1d405b635b66aca61c1bbf https://doi.org/10.1002/anie.201305778 Zobrazit plný text záznamu Plný text