Protein degradation in red cells exposed to 2,2'-azo-bis(2-amidinopropane) derived radicals
| Autor: | Eduardo Lissi, Gloria Celedón, M. Cortés, Gustavo González, V. Lips, C. Alvarado |
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| Rok vydání: | 1998 |
| Předmět: |
Erythrocytes
Free Radicals Radical Clinical Biochemistry Amidines Protein degradation Photochemistry Biochemistry Hemolysis Lipid peroxidation chemistry.chemical_compound Endopeptidases Genetics medicine Humans Fragmentation (cell biology) Molecular Biology Band 3 Chromatography biology Red Cell Hydrolysis Erythrocyte Membrane Cell Biology Blood Proteins medicine.disease Oxidants Blood proteins Peroxides chemistry biology.protein Lipid Peroxidation |
| Zdroj: | Biochemistry and molecular biology international. 43(5) |
| ISSN: | 1039-9712 |
| Popis: | Extensive proteolysis is observed when red blood cells are exposed to free radicals produced in the thermolysis of 2,2'-azo-bis(2-amidinopropane). It is evaluated that nearly one amino terminal group is produced by each free radical introduced into the system. These groups are considered to arise mainly from band 3 fragmentation due to the action of red cell proteinases. Protein fragmentation takes place prior to significant hemolysis or lipid peroxidation, as evaluated by thiobarbituric acid-reactive substances measurements. |
| Databáze: | OpenAIRE |
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