Impact of depression on gait variability in Parkinson’s disease
| Autor: | Igor Petrović, Milica Đurić-Jovičić, Nataša Dragašević-Mišković, Kosta Dimitrijević, Sasa Radovanovic, Marina Svetel, Iva Stankovic, Vladislava Bobic, Milutin Kostić |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease STRIDE Walking Executive Function Random Allocation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Rating scale medicine Humans Gait Gait Disorders Neurologic Depression (differential diagnoses) Aged Depressive Disorder Major Depression business.industry Gait variability Parkinson Disease Cognition General Medicine Middle Aged Executive functions medicine.disease 030220 oncology & carcinogenesis Gait analysis Dual-task paradigm Accidental Falls Female Surgery Neurology (clinical) business human activities Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurology & Neurosurgery |
| ISSN: | 0303-8467 |
| DOI: | 10.1016/j.clineuro.2020.106324 |
| Popis: | Objective The goal of this study was to analyze how depression associated with Parkinson’s disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Patients and Methods Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods. Results Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients. Conclusions Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task. Significance Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients. |
| Databáze: | OpenAIRE |
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