Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Autor:	Ruyu, Wang, Guanglei, Zhai, Guanghao, Zhu, Mengge, Wang, Xiaoyi, Gong, Weidong, Zhang, Guangbo, Ge, Hongzhuan, Chen, Lili, Chen
Rok vydání:	2023
Předmět:	Viral Protease Inhibitors SARS-CoV-2 Organic Chemistry Antiviral Agents Biochemistry COVID-19 Drug Treatment Molecular Docking Simulation Quaternary Ammonium Compounds Pyrimidines Endopeptidases Drug Discovery Humans Molecular Biology Peptide Hydrolases
Zdroj:	Bioorganic Chemistry. 130:106264
ISSN:	0045-2068
Popis:	Although the effective drugs or vaccines have been developed to prevent the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their efficacy may be limited for the viral evolution and immune escape. Thus, it is urgently needed to develop the novel broad-spectrum antiviral agents to control the coronavirus disease 2019 (COVID-19) global pandemic. The 3C-like protease (3CL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f35b07aad2052c6c8e5704c8c17180 https://doi.org/10.1016/j.bioorg.2022.106264 Zobrazit plný text záznamu Full Text from ScienceDirect