Laminar flow assisted anisotropic bacteria absorption for chemotaxis delivery of bacteria-attached microparticle
| Autor: | Keon Huh, Seok Young Son, Darong Oh, Byeonghwa Song, Sung Jae Kim, Jong-Mo Seo, Dong-il Dan Cho, Hyung Jung Yoo |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
biology 010401 analytical chemistry Microfluidics Biomedical Engineering Nanotechnology Laminar flow Chemotaxis 02 engineering and technology 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Biodegradable polymer 0104 chemical sciences Biomaterials Drug delivery Microparticle Absorption (chemistry) 0210 nano-technology Bacteria Biomedical engineering |
| Zdroj: | Micro and Nano Systems Letters. 4 |
| ISSN: | 2213-9621 |
| DOI: | 10.1186/s40486-016-0026-6 |
| Popis: | The concepts of microrobots has been drawn significant attentions recently since its unprecedented applicability in nanotechnology and biomedical field. Bacteria attached microparticles presented in this work are one of pioneering microrobot technology for self-propulsion or producing kinetic energy from ambient for their motions. Microfluidic device, especially utilizing laminar flow characteristics, were employed for anisotropic attachment of Salmonella typhimurium flagellated chemotactic bacteria to 30 um × 30 um and 50 um × 50 um microparticles that made of biodegradable polymer. Any toxic chemicals or harmful treatments were excluded during the attachment process and it finished within 100 s for the anisotropic attachment. The attachments were directly confirmed by fluorescent intensity changes and SEM visualization. Chemotaxis motions were tracked using aspartate and the maximum velocity of the bacteria-attached microrobot was measured to be ~5 um/s which is comparable to prior state of art technologies. This reusable and scalable method could play a key role in chemotaxis delivery of functional microparticles such as drug delivery system. |
| Databáze: | OpenAIRE |
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