The Impact of Posture on Cardiac Repolarization: More Than Heart Rate?

Autor:	Katherine M. Dunnington, Zhiming Wang, Edward K. Hill, Thomas R. Zimmerman, Maxine Stoltz, Kerry B. Hafner, Jean T. Barbey, Ming-yi Hu, Gregory C. Williams
Rok vydání:	2006
Předmět:	Male medicine.medical_specialty Supine position Correction method Posture Cardiac repolarization QT interval Electrocardiography Heart Rate Reference Values Physiology (medical) Internal medicine Heart rate medicine Humans cardiovascular diseases Framingham Risk Score medicine.diagnostic_test Physiological control business.industry Anesthesia cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies
Zdroj:	Journal of Cardiovascular Electrophysiology. 17:352-358
ISSN:	1540-8167 1045-3873
DOI:	10.1111/j.1540-8167.2005.00415.x
Popis:	The Impact of Posture on Cardiac Repolarization: More Than Heart Rate? Introduction: The effect of standing on heart rate and QT is well known but its impact on QTc is less clear. Methods: Serial supine and standing 12-lead ECGs (seven pairs each day) were recorded from 54 healthy volunteers each day of a three-day period. ECGs were captured digitally and over-read by a cardiologist. Results: A statistically significant shortening of RR (216 ms), QT (40 ms), and decreases in QTc-F (Fridericia) and QTc-LR (Framingham) were demonstrated on standing (8.3 and 6.9 ms, respectively). In contrast, QTc-B (Bazett's) significantly increased by 9.6 ms. Two subject-individualized correction methods were derived using each subject's supine measurements. Both showed significant decreases in QTc of approximately 13-14 ms upon standing. Using the bin analysis method, comparisons between positions using 25 ms interval RR bins revealed significant QT shortening of up to 15 ms upon standing. Conclusion: We have demonstrated a postural effect on cardiac repolarization independent of heart rate using two individualized correction methods, as well as QTc-F and QTc-LR, and the bin method. Characterization of postural differences in QT/QTc (other than QTc-B) may provide a safe and inexpensive physiological control to validate the ECG methodology used in clinical trials to assess potential drug-induced QT interval changes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f2b6526f055d9ec9d1d7ff8bcad961 https://doi.org/10.1111/j.1540-8167.2005.00415.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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