Hydroxyapatite phagocytosis by human polymorphonuclear leucocytes
| Autor: | K H Maurer, H R Schumacher |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cell necrosis
Time Factors Neutrophils Phagocytosis Immunology Arthritis General Biochemistry Genetics and Molecular Biology law.invention Microbiology Rheumatology law Humans Immunology and Allergy Medicine Incubation business.industry Degranulation medicine.disease In vitro Microscopy Electron Cytoplasm Hydroxyapatites Electron microscope business Research Article |
| Zdroj: | Annals of the Rheumatic Diseases. 38:84-88 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.38.1.84 |
| Popis: | Hydroxyapatite crystals were incubated with human polymorphonuclear leucocytes and samples examined by light and electron microscopy after 3, 8, 30, and 120 minutes' incubation. Phagocytosis of crystals occurred at 3 minutes and increased with incubation. Degranulation of neutrophils, loss of cytoplasmic density, and cell necrosis were greatest in cells mixed with apatite and increased with time. Avid in vitro phagocytosis of hydroxyapatite crystals lends further support to the potential of these crystals as causes of human arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|