Validation of an algorithm combining haemoglobin A(1c) and fasting plasma glucose for diagnosis of diabetes mellitus in UK and Australian populations
| Autor: | R. A. Round, Z. X. Lu, Susan E. Manley, Peter Nightingale, Stephen C. L. Gough, Ken Sikaris, Irene M Stratton, V. Baskar, J. M. Smith |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male endocrine system diseases Endocrinology Diabetes and Metabolism Population Sensitivity and Specificity Prediabetic State chemistry.chemical_compound Endocrinology Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Humans education Glycated haemoglobin Aged Glycated Hemoglobin education.field_of_study Glucose tolerance test Plasma glucose medicine.diagnostic_test business.industry Australia nutritional and metabolic diseases Reproducibility of Results Fasting Glucose Tolerance Test Middle Aged medicine.disease Impaired fasting glucose United Kingdom Hemoglobin A chemistry Female Glycated hemoglobin business Algorithm Algorithms |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 26(2) |
| ISSN: | 1464-5491 |
| Popis: | Aim To determine whether glycated haemoglobin (HbA1c) can be used in combination with fasting plasma glucose (FPG) for the diagnosis of diabetes in patients with impaired fasting glucose (IFG) and in a broader spectrum of patients. Methods An algorithm was derived from oral glucose tolerance test (OGTT) capillary samples in 500 consecutive UK patients with IFG by World Health Organization criteria. It was validated in a further 500 UK patients and, with venous specimens, in 1175 unselected Australian patients. Results The derivation cohort was aged 61 years (50–69 years) (median IQ range) with 52% male and 12% South Asian. Diabetes Control and Complications Trial-aligned HbA1c was 6.2% (5.8–6.6%) (reference interval |
| Databáze: | OpenAIRE |
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