The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol
| Autor: | Peter Furu, Leon Brimer, M. Kady, Else Lemmich, Helle Nielsen, Ole Thastrup, Susanne T. Thiilborg, Søren Brøgger Christensen |
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| Rok vydání: | 1992 |
| Předmět: |
Molluscacides
Bulinus Bulinus truncatus Pharmaceutical Science Anticoagulant activity Analytical Chemistry Coumarins parasitic diseases Drug Discovery Botany medicine Biomphalaria glabrata Animals Pharmacology Plants Medicinal biology Traditional medicine Biomphalaria Organic Chemistry Ethulia conyzoides Anticoagulants Dicoumarol biology.organism_classification Complementary and alternative medicine Coumarin anticoagulant Molluscicide Molecular Medicine medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0032-0943 |
| Popis: | The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity. |
| Databáze: | OpenAIRE |
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