Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults
| Autor: | Wangqiang Hu, Hong Lu, Rongrong Yang, Zhuo Zhang, Lianfeng Wu, Xiaoxia Wang, Laixi Bi, Yaosheng Xie |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent CD33 Central nervous system chemical and pharmacologic phenomena CD15 Gastroenterology Central Nervous System Neoplasms Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Immunophenotyping Risk Factors Internal medicine Acute lymphocytic leukemia Biomarkers Tumor Humans Medicine Cumulative incidence Risk factor business.industry hemic and immune systems Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease CD56 Antigen stomatognathic diseases Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female CD5 business 030215 immunology |
| Zdroj: | Hematology. 22:81-87 |
| ISSN: | 1607-8454 |
| Popis: | Objective: To gain further insights into the predisposing risk factors for central nervous system (CNS) involvement in patients with acute lymphocytic leukemia (ALL), the impact of CD56 expression in these patients was investigated.Methods: We reviewed the clinical features of CD56 expression in 588 consecutive ALL patients treated with systemic chemotherapy regimens between 2000 and 2014. The categorical data from CD56+ ALL patients were compared with those from CD56− ALL patients.Results: Among the 588 patients studied, 18.9% showed CD56 expression. The expression was significantly associated with CD33+, CD10−, CD15+, TdT−, and CD5+ immunophenotypes. After systemic chemotherapy, 8.8% patients showed CNS involvement, of which 3.2% exhibited combined recurrences and 5.6% exhibited isolated CNS involvement. The 5-year event-free survival was significantly lower for patients with CD56+ immunophenotype compared with patients with CD56− immunophenotype (22.5% vs. 32.7%, P = 0.04). Cumulative incidence... |
| Databáze: | OpenAIRE |
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