The role of heparin therapy in Dispholidus typus envenomation: an experimental study
| Autor: | M. Rebello, M.C. Gaillard, B.A. Bradlow, P.M. Atkinson |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Swine
Antithrombin III Venom Pharmacology Viper Venoms complex mixtures Fibrin Fibrinogen Degradation Products Thrombin medicine Animals Humans Envenomation Blood Coagulation Disseminated intravascular coagulation Factor VIII business.industry Heparin Platelet Count Antithrombin Fibrinogen Heparin Antagonists Hematology Disseminated Intravascular Coagulation medicine.disease Coagulation Immunology Cattle Rabbits business circulatory and respiratory physiology medicine.drug Snake Venoms |
| Zdroj: | Thrombosis research. 23(4-5) |
| ISSN: | 0049-3848 |
| Popis: | Dispholidus typus venom displays heparin resistance in that more heparin is required to prevent coagulation due to this venom, than to coagulation due to either Russell's viper venom or activation of the intrinsic pathway. Using pure prothrombin, pure antithrombin III and chromogenic substrates it was demonstrated that the resistance was not due to destruction of antithrombin III or heparin, or to the possible production of an antithrombin III resistant form of thrombin. The resistance could however be overcome in vitro at heparin venom ratios that could also be attained in vivo . In vivo studies in rabbits indicated that early heparin therapy delayed but did not prevent the onset of disseminated intravascular coagulation. |
| Databáze: | OpenAIRE |
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