The levels of phthalate exposure and associations with obesity in an elderly population in China
| Autor: | De-Xiang Xu, Xiude Li, Hongjuan Cao, Fangbiao Tao, Shun Feng, Hui Gao, Yan-Ling Li, Qunan Wang, Kaiyong Liu, Zhi-ping Du, Jie Sheng, Linsheng Yang, Jia Lv, Zhong-xiu Jin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
China Waist Health Toxicology and Mutagenesis Phthalic Acids 0211 other engineering and technologies Physiology 02 engineering and technology Urine 010501 environmental sciences 01 natural sciences Body Mass Index Cohort Studies chemistry.chemical_compound Sex Factors medicine Humans Obesity Abdominal obesity Aged 0105 earth and related environmental sciences 021110 strategic defence & security studies business.industry Confounding Public Health Environmental and Occupational Health Phthalate Environmental Exposure General Medicine medicine.disease Pollution chemistry Cohort Environmental Pollutants Female medicine.symptom business Body mass index |
| Zdroj: | Ecotoxicology and Environmental Safety. 201:110749 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/j.ecoenv.2020.110749 |
| Popis: | Background Few epidemiological studies on the correlation between phthalate exposure and elderly obesity in China are available. The purpose of the present study is to assess phthalate exposure levels and explore the connections between exposure to phthalates and obesity using a sample of Chinese community-dwelling elderly individuals. Methods Data were acquired from the baseline survey of the Cohort of Health of Elderly and Controllable Factors of Environment, which was established in Lu'an, Anhui province, China, from June to September in 2016. Urine samples were obtained to analyze the concentrations of seven phthalate metabolites, utilizing a high-performance liquid chromatography–tandem mass spectrometry method. General obesity was determined based on body mass index, and abdominal obesity based on waist circumference. Binary logistic regression models were utilized to analyze the associations of creatinine-corrected phthalate metabolite concentrations (categorized into quartiles) with general and abdominal obesity in elderly people. Moreover, a stratified analysis was performed to explore the difference between genders. Results Of 942 elderly individuals, 52.9% were defined as generally obese and 75.5% as abdominally obese. The detection rates of seven phthalate metabolites ranged from 90.07% to 99.80%. The highest median concentration was 44.08 μg/l (for MBP), and the lowest was 0.55 μg/l (for MEHP). The level of exposure to LMW(low-molecular-weight) PAEs is higher than that to HMW(high-molecular-weight) PAEs. After adjustment for confounding variables, we found a significant association between urinary MEOHP (mono-2-ethyl-5-oxohexyl phthalate), MEHP (mono-2-ethylhexyl phthalate), MBP (mono-n-butyl phthalate), MEP (mono-ethyl phthalate), and MMP (mono-methyl phthalate) levels and general obesity. MBP levels were also correlated with abdominal obesity. When stratified by gender, higher urinary levels of MEOHP, MBP, MEP, and MMP were associated with general obesity in males, whereas MBP and MMP levels were eminently correlated with general obesity in females. Higher urinary MBP levels were associated with increased abdominal obesity rates in males, but not in females. Conclusions In conclusion, higher phthalate metabolite concentrations were correlated with obesity in the elderly. Moreover, a gender difference was observed in these associations. |
| Databáze: | OpenAIRE |
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