Is endocan a biochemical marker for asymptomatic target organ damage in hypertensive patients?
| Autor: | Ağaç, Mustafa Tarık, Behlul Kahyaoglu, Muhammed Murat Necati Aksoy, Cinemre, Fatma Behice, Vatan, Mehmet Bülent, Gündüz, Yasemin |
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| Přispěvatelé: | Agac, MT, Kahyaoglu, B, Aksoy, MMN, Cinemre, FB, Vatan, MB, Gunduz, Y, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Ağaç, Mustafa Tarık, Cinemre, Fatma Behice, Vatan, Mehmet Bülent, Gündüz, Yasemin |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty hypertension Renal function Blood Pressure Disease 030204 cardiovascular system & hematology Asymptomatic Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Endothelial dysfunction Original Investigation endocan business.industry asymptomatic target organ damage Middle Aged medicine.disease Target organ damage Pulse pressure Neoplasm Proteins Blood pressure Cardiovascular Diseases Cardiology Cardiovascular System & Cardiology Biomarker (medicine) Female Kidney Diseases Proteoglycans medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Anatolian Journal of Cardiology |
| ISSN: | 2149-2271 2149-2263 |
| Popis: | Objective Identification of the asymptomatic target organ damage (AOD) helps to stratify the overall risk of cardiovascular (CV) diseases and guides a treatment decision in hypertensive patients without a symptomatic CV or renal disease. The endothelial-cell-specific molecule 1 (endocan) is regarded as a novel marker of endothelial dysfunction. Its release is increased in hypertensive patients, especially those with symptomatic CV and renal disease. In the present study, we aimed to evaluate the endocan levels in asymptomatic hypertensive patients with or without AOD. Methods The study included 132 asymptomatic hypertensive patients, and 101 of who had at least one AOD. Results Serum endocan levels did not differ between patients with and without AOD (3.81±0.78 vs. 3.83±0.63 ng/mL, p=0.88). An analysis according to the presence of any specific AOD did not show any difference between groups. No significant correlation was found between serum endocan levels and any of the continuous variables related to AOD, such as the pulse pressure, carotid intimae-media thickness, cardio-ankle vascular index, ankle-brachial index, left ventricular mass index, Sokolow-Lyon index, Cornell voltage-duration product, and estimated glomerular filtration rate. Conclusion Endocan may not serve as a useful biomarker at asymptomatic vascular stages of hypertension, despite its role in indicating disease severity and inflammatory activation in advanced symptomatic CV and renal disease. |
| Databáze: | OpenAIRE |
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