Anti-Müllerian Hormone Gene Polymorphism is Associated with Clinical Pregnancy of Fresh IVF Cycles
| Autor: | Tsung-Hsien Lee, Maw-Sheng Lee, Yu-Jun Chang, Hui-Mei Tsao, Shun-Fa Yang, Cheng-Hsuan Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Anti-Mullerian Hormone
Multivariate analysis Pregnancy Rate Health Toxicology and Mutagenesis medicine.medical_treatment lcsh:Medicine Anti-Müllerian hormone Polymerase Chain Reaction law.invention 0302 clinical medicine Pregnancy law Genotype Ethnicity Prospective Studies Prospective cohort study Polymerase chain reaction 0303 health sciences 030219 obstetrics & reproductive medicine biology female genital diseases and pregnancy complications Female hormones hormone substitutes and hormone antagonists Adult Receptors Peptide Taiwan Single-nucleotide polymorphism Fertilization in Vitro Polymorphism Single Nucleotide Article Andrology 03 medical and health sciences medicine IVF outcomes Humans 030304 developmental biology In vitro fertilisation urogenital system business.industry lcsh:R Public Health Environmental and Occupational Health AMHRII polymorphism Anti-Müllerian hormone type II receptor biology.protein AMH polymorphism business Receptors Transforming Growth Factor beta Hormone |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 5 International Journal of Environmental Research and Public Health, Vol 16, Iss 5, p 841 (2019) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16050841 |
| Popis: | The aim of this study was to examine the effects of single-nucleotide polymorphisms (SNPs) in the anti-Mü llerian hormone (AMH) and AMH type II receptor (AMHRII) genes on in vitro fertilization (IVF) outcomes. In this prospective cohort study, we genotyped the AMH 146 T > G, AMHRII &minus 482 A > G and AMHRII IVS1 +149 T > A variants in 635 women undergoing their first cycle of controlled ovarian stimulation for IVF. DNA was extracted from the peripheral blood of all participants, and the SNPs were genotyped by real-time polymerase chain reaction. The distributions, frequencies of genes, and correlation with clinical pregnancy of IVF were analyzed. The AMH 146 T > G G/G genotype in women was associated with a lower clinical pregnancy rate (T/T: 55.0%, T/G: 51.8%, G/G: 40.0% p < 0.05). Women with the AMH 146 T > G GG genotype were half as likely to have a clinical pregnancy compared with women with TT genotypes (OR = 0.55, 95% CI: 0.34&ndash 0.88, p = 0.014). With multivariate analysis, the AMH 146 T > G GG genotype remains as a significant independent factor to predict clinical pregnancy (p = 0.014). No significant difference was found between AMHRII polymorphisms and clinical pregnancy outcomes of IVF. In conclusion, our results show that AMH 146 T > G seems to be a susceptibility biomarker capable of predicting IVF pregnancy outcomes. Further studies should focus on the mechanism of these associations and the inclusion of other ethnic populations to confirm the findings of this study. |
| Databáze: | OpenAIRE |
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