Comparison of silver sulphadiazine 1 per cent, silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent and mafenide acetate 8.5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds
| Autor: | M. Forbes, Charles F. T. Snelling, E. Germann, D.A. Henry, J.H. Gray, Frederick J. Roberts |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Mafenide
medicine.medical_specialty Veterinary medicine medicine.drug_class Administration Topical Eschar Critical Care and Intensive Care Medicine Silver sulfadiazine Enterococcus faecalis Random Allocation Chlorhexidine digluconate Antiseptic Animals Medicine biology business.industry Chlorhexidine Rats Inbred Strains Bacterial Infections General Medicine biology.organism_classification Silver Sulfadiazine Rats Surgery Emergency Medicine Drug Therapy Combination Female medicine.symptom Burns business Enterobacter cloacae medicine.drug |
| Zdroj: | Burns. 17:37-40 |
| ISSN: | 0305-4179 |
| Popis: | Silver sulphadiazine 1 per cent (SS), silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (SS + CD 0.2 per cent) and mafenide acetate 8.5 per cent (MA) were compared to assess the antibacterial effect of once daily application on experimental rat 20 per cent full skin thickness burn wounds seeded 24 h earlier with 10(8) microorganisms originally isolated from infected wounds of burned patients. Separate series evaluated Staph. aureus, Enterococcus faecalis, Enterobacter cloacae and Ps. aeruginosa. The mean concentration of all four organisms recovered after 1 week from full thickness biopsies of eschar and from separate biopsies of subjacent muscle was less in MA and SS + CD 0.2 per cent treated animals compared with those treated with SS alone. The mean concentration in muscle and eschar following treatment with MA was less for wounds seeded with Staph. aureus and Ps. aeruginosa than with SS + CD 0.2 per cent treatment, while the mean concentration in eschar application of SS + CD 0.2 per cent was less than with MA for E. faecalis seeded wounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|