A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate
| Autor: | Jorge F. Rodriguez-Sierra, D. A. Crouse, John G Sharp, M. Olubunmi Dada, Charles A. Blake |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Lipopolysaccharide T cell T-Lymphocytes Spleen Stimulation Thymus Gland Lymphocyte Activation General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Immune system Glutamates Internal medicine Sodium Glutamate medicine Endocrine system Animals Castration General Pharmacology Toxicology and Pharmaceutics B-Lymphocytes biology business.industry Rats Inbred Strains General Medicine Organ Size Luteinizing Hormone Rats medicine.anatomical_structure Endocrinology chemistry Animals Newborn Concanavalin A biology.protein Follicle Stimulating Hormone Mitogens business |
| Zdroj: | Life sciences. 35(7) |
| ISSN: | 0024-3205 |
| Popis: | We investigated whether administration of monosodium 1-glutamate (MSG) to neonatal rats would disrupt immune responses in intact and orchidectomized adult male rats. Neonatal male rats were treated with saline or MSG which causes severe endocrine abnormalities. Half of each group of animals were orchidectomized as adults and killed one week later along with intact rats. MSG treatment resulted in suppressed serum LH levels in intact rats. Thymus weight and spleen cellularity in intact animals were not affected by MSG treatment, but thymus weight increased within one week after orchidectomy in both saline- and MSG-treated groups. In intact rats, lymphocyte stimulation by the T cell specific mitogens (concanavalin A or phytohemagglutinin) or the B cell specific mitogen (lipopolysaccharide) was unaffected by prior treatment with MSG. However, MSG treatment blocked the decrease attributable to orchidectomy in concanavalin A and phytohemagglutinin stimulation of lymphocyte blastogenesis. The results suggest that administration of MSG to neonatal male rats can alter some immune responses in the adult animal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|