BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma
| Autor: | Anthony E. James, Q. Li, Nelson L.S. Tang, Ben Chung-Lap Chan, Paul B.S. Lai, K.-N. Lai, Pak Leong Lim, S. Chen, J. Y.-H. Chan, Yiu-Loon Chui, Pang-Chui Shaw, J. C.-K. Leung, K. K.-H. Lee, Arthur K.K. Ching, Ka Fai To |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
medicine.medical_specialty Carcinoma Hepatocellular Apoptosis Mice Transgenic Nerve Tissue Proteins Biology medicine.disease_cause Jurkat Cells Mice Antibody Specificity In vivo Cell Line Tumor Internal medicine Genetics medicine Animals Humans Molecular Biology Mice Inbred ICR Liver Neoplasms Intrinsic apoptosis Antibodies Monoclonal Lewis lung carcinoma Transfection Endocrinology Cell culture Cancer research Tumor necrosis factor alpha Apoptosis Regulatory Proteins Carcinogenesis HeLa Cells |
| Zdroj: | Oncogene. 27:1208-1217 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1210733 |
| Popis: | BRE binds to the cytoplasmic domains of tumor necrosis factor receptor-1 and Fas, and in cell lines can attenuate death receptor-initiated apoptosis by inhibiting t-BID-induced activation of the mitochondrial apoptotic pathway. Overexpression of BRE by transfection can also attenuate intrinsic apoptosis and promote growth of the transfected Lewis lung carcinoma line in mice. There is, however, a complete lack of in vivo data about the protein. Here, we report that by using our BRE-specific monoclonal antibody on the immunohistochemistry of 123 specimens of human hepatocellular carcinoma (HCC), significant differences in BRE expression levels between the paired tumoral and non-tumoral regions (P |
| Databáze: | OpenAIRE |
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