A Randomized Control Trial of 3 IU IV Oxytocin Bolus with 7 IU Oxytocin Infusion versus 10 IU Oxytocin Infusion During Cesarean Section for Prevention of Postpartum Hemorrhage
| Autor: | Rajasri G Yaliwal, Shreedevi S Kori, Neelamma Patil, Shobha S. Shiragur, Subhashchandra R Mudanur, Sangamesh S. Mathapati, Prathibha S Dharmarao, Aruna M Biradar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Uterus International Journal of Women's Health Hemodynamics Hemoglobin levels Oxytocin law.invention 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Randomized controlled trial Blood loss law Maternity and Midwifery Medicine 030212 general & internal medicine blood loss Adverse effect Original Research 030219 obstetrics & reproductive medicine cesarean section business.industry Obstetrics and Gynecology hemoglobin medicine.anatomical_structure Oncology Anesthesia uterine tone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | International Journal of Women's Health |
| ISSN: | 1179-1411 |
| Popis: | Rajasri G Yaliwal,1 Aruna M Biradar,1 Prathibha S Dharmarao,2 Shreedevi S Kori,1 Subhashchandra R Mudanur,1 Neelamma G Patil,1 Shobha S Shiragur,1 Sangamesh S Mathapati1 1Department of OBGYN, BLDE (DU) Shri B. M. Patil Medical College Hospital and Research Center, Vijayapura, Karnataka, India; 2Department of Anesthesiology, BLDE (DU) Shri B. M. Patil Medical College Hospital and Research Center, Vijayapura, Karnataka, IndiaCorrespondence: Aruna M Biradar; Rajasri G YaliwalDepartment of OBGYN, BLDE (DU) Shri B.M. Patil Medical College, Hospital and Research Center, Vijayapura, Karnataka, IndiaTel +91 81971 91472; +91 98451 52240Fax +91 8352 263303Email aruna.biradar@bldedu.ac.in; ryaliwal@bldedu.ac.inPurpose: Oxytocin is the preferred choice for prophylaxis and treatment of postpartum hemorrhage. Intravenous infusion has been a widely accepted route for Oxytocin administration. However, intravenous bolus route is not a readily preferred route due to apprehensions regarding hypotension that it may cause. This trial compares low dose 3 IU intravenous (IV) bolus Oxytocin along with 7 IU Oxytocin in intravenous infusion to 10IU Oxytocin intravenous infusion during cesarean section.Patients and Methods: A total of 250 term pregnant women were randomized to either 3 IU intravenous bolus with 7 IU intravenous infusion of Oxytocin or 10IU of intravenous Oxytocin infusion. The difference in pre- and post-operative hemoglobin levels, tone of the uterus, hemodynamic changes, adverse effects of the drug, need for additional uterotonics and need for blood transfusions were assessed.Results: There was 6.7% less blood loss in the 3 IU IV bolus Oxytocin with 7 IU Oxytocin infusion group in comparison to the Oxytocin infusion group. The tone of the uterus was firmer in IV bolus Oxytocin with Oxytocin infusion group at 5 minutes (p< 0.001) than the Oxytocin infusion group. There was no significant difference in the hemodynamic changes, adverse effects or need for blood transfusions.Conclusion: Intravenous bolus of 3 IU Oxytocin along with 7 IU infusion of Oxytocin is as safe and more effective than intravenous infusion of 10 IU of Oxytocin during cesarean section in the prevention of postpartum hemorrhage.Keywords: Oxytocin, cesarean section, blood loss, hemoglobin, uterine tone |
| Databáze: | OpenAIRE |
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