The lipid biology of sepsis

Autor: David A. Ford, Daniel P. Pike, Kaushalya Amunugama
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
SIRS
systemic inflammatory response syndrome

TXB2
thromboxane B2

ARDS
LPCAT
lysophosphatidylcholine acyltransferase

HOCl
hypochlorous acid

MPO
myeloperoxidase

AA
arachidonic acid

030204 cardiovascular system & hematology
Bioinformatics
Biochemistry
Pathogenesis
TPPU
N-[1-(1-oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

chemistry.chemical_compound
PC
phosphatidylcholine

0302 clinical medicine
Endocrinology
AEA
N-arachidonoylethanolamine

prognostics
lipid metabolism
DHET
dihydroxyeicosatrienoic acid

LOX
lipoxygenase

2-ClSA
2-chlorostearic acid

ATX
autotaxin

cys-LTs
cysteinyl leukotrienes

Rv
resolvin

TG
triglycerides

CLP
cecal ligation puncture

Lipids
SPMs
specialized pro-resolving mediators

2-ClFALD
2-chlorofatty aldehyde

LPS
lipopolysaccharide

RvE1-RvE3
E series resolvins

sPLA2
secretory phospholipase A2

medicine.symptom
Resolvin
LPA
lysophosphatidic acid

bioactive lipids
CEPT
cholesteryl ester transfer

rHDL
recombinant HDL

LTB4
leukotriene B4

RvT1-RvT4
T series resolvins

Inflammation
Cer
ceramide

CS
cecal slurry

QD415-436
Biology
fatty acids
TLR
Toll-like receptors

Sepsis
03 medical and health sciences
2-ClFA
2-chlorofatty acid

medicine
energy imbalance
Humans
cPLA2
cytosolic PLA2

PAF
platelet-activating factor

ARDS
acute respiratory distress syndrome

RvD1-RvD6
D series resolvins

DPA
docosapentaenoic acid

S1P
sphingosine-1-phosphate

2-ClPA
2- chloropalmitic acid

LPC
lysophosphatidylcholine

Organ dysfunction
PLA2
phospholipase A2

EET
epoxy-eicosatrienoic acid

cholesterol
biomarkers
resolution
Lipid metabolism
Thematic Review Series
Cell Biology
Sphk
sphingosine kinase

SOFA
sequential organ failure assessment

medicine.disease
sEH
soluble epoxide hydrolase

Systemic inflammatory response syndrome
COX
cyclooxygenase

TC
total cholesterol

030104 developmental biology
chemistry
LTA
lipotechoic acid

inflammation
10S
17S- diHDHA
10(S)
17(S) dihydroxy docosahexaenoic acid

sepsis pathogenesis
CYP450
cytochrome P450

PCSK9
proprotein convertase subtilisin/kexin type 9

2-AG
2-Arachidonoylglycerol
Zdroj: Journal of Lipid Research, Vol 62, Iss, Pp 100090-(2021)
Journal of Lipid Research
ISSN: 0022-2275
Popis: Sepsis, defined as the dysregulated immune response to an infection leading to organ dysfunction, is one of the leading causes of mortality around the globe. Despite the significant progress in delineating the underlying mechanisms of sepsis pathogenesis, there are currently no effective treatments or specific diagnostic biomarkers in the clinical setting. The perturbation of cell signaling mechanisms, inadequate inflammation resolution, and energy imbalance, all of which are altered during sepsis, are also known to lead to defective lipid metabolism. The use of lipids as biomarkers with high specificity and sensitivity may aid in early diagnosis and guide clinical decision making. In addition, identifying the link between specific lipid signatures and their role in sepsis pathology may lead to novel therapeutics. In this review, we discuss the recent evidence on dysregulated lipid metabolism both in experimental and human sepsis focused on bioactive lipids, fatty acids, and cholesterol as well as the enzymes regulating their levels during sepsis. We highlight not only their potential roles in sepsis pathogenesis but also the possibility of using these respective lipid compounds as diagnostic and prognostic biomarkers of sepsis.
Graphical abstract
Databáze: OpenAIRE
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