Abnormal Attention Modulation of Fear Circuit Function in Pediatric Generalized Anxiety Disorder
Autor: | Christopher S. Monk, Ellen Leibenluft, Abby D. Adler, Jessica M. Parrish, R. James R. Blair, Erin B. McClure, Monique Ernst, Stephen J. Fromm, Dennis S. Charney, Daniel S. Pine, Eric E. Nelson |
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Rok vydání: | 2007 |
Předmět: |
Male
medicine.medical_specialty Generalized anxiety disorder Adolescent Emotions Prefrontal Cortex Audiology Gyrus Cinguli Amygdala Fear-potentiated startle Functional Laterality Developmental psychology Arts and Humanities (miscellaneous) Neural Pathways medicine Humans Attention Child Anterior cingulate cortex Fear processing in the brain Brain Mapping medicine.diagnostic_test Brain Fear medicine.disease Anxiety Disorders Magnetic Resonance Imaging Facial Expression Oxygen Psychiatry and Mental health medicine.anatomical_structure Social Perception Adolescent Behavior Case-Control Studies Visual Perception Anxiety Female Cues medicine.symptom Psychology Functional magnetic resonance imaging Anxiety disorder |
Zdroj: | Archives of General Psychiatry. 64:97 |
ISSN: | 0003-990X |
Popis: | Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues.To determine whether attention modulates amygdala and cortical responses to facial-threat cues differentially in adolescents with generalized anxiety disorder and in healthy adolescents.Case-control study.Government clinical research institute.Fifteen adolescents with generalized anxiety disorder and 20 controls.Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging. During imaging, participants completed a face-emotion rating task that systematically manipulated attention.While attending to their own subjective fear, patients, but not controls, showed greater activation to fearful faces than to happy faces in a distributed network including the amygdala, ventral prefrontal cortex, and anterior cingulate cortex (P.05, small-volume corrected, for all). Right amygdala findings appeared particularly strong. Functional connectivity analyses demonstrated positive correlations among the amygdala, ventral prefrontal cortex, and anterior cingulate cortex.This is the first evidence in juveniles that generalized anxiety disorder-associated patterns of pathologic fear circuit activation are particularly evident during certain attention states. Specifically, fear circuit hyperactivation occurred in an attention state involving focus on subjectively experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping the function of the adolescent human fear circuit. |
Databáze: | OpenAIRE |
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