ANTIMICROBIOLOGICAL EFFECTS OF NEW NATURAL ANTISEPTIC FORMULATION ON NON-INFECTED VENOUS LEG ULCER: PILOT STUDY
| Autor: | Đorđe Gocev, Aleksandar Jankovic, Ivana Binić, Dimitrije Janković, Milan Miladinović, Zoran Vrućinić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Astringent medicine.drug_class medicine.medical_treatment DermaplantG hydrogel Population lcsh:Medicine Venous leg ulcer Gastroenterology Industrial and Manufacturing Engineering venous leg ulcer Antiseptic Internal medicine medicine education Saline education.field_of_study business.industry lcsh:R Antimicrobial medicine.disease Surgery Anaerobic bacteria microbiological flora Wound healing business |
| Zdroj: | Acta Medica Medianae, Vol 50, Iss 3, Pp 40-44 (2011) |
| ISSN: | 0365-4478 |
| Popis: | Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as antimicrobial, antifungal, astringent etc. The aim of the study was to establish the in-vivo antimicrobial effects of herbal hydrogel formulation DermaplantG. The major components of the DermaplantG were the extracts of Allii bulbus, Hyperici herba and extract of Calendulae flos. A total of 12 patients with non-infected venous leg ulcers were treated twice daily, for 5 weeks, with new hydrogel formulation. All ulcers showed clinical signs of contamination or colonization without signs of systemic infection. Premoistening the swab with sterile saline was considered when the surface of the wound was dry. The tip of the swab was rolled on its side in a zigzag pattern for at least one full rotation. Standard methods for isolation and identification of aerobic and anaerobic bacteria were used. On baseline assessment, a large number of different types of bacteria were detected in all venous leg ulcers. S. aureus and P. aeruginosa were isolated from almost all controls. On baseline, mixed bacterial flora (50%) was isolated in six venous leg ulcers (five ulcers with S. aureus-P. aeruginosa and one ulcer with E.coli-Enterobacter sppP.aeruginosa). At the end of the treatment in DermaplantG group in 8 venous ulcers were detected S. aureus (66.66%) and P. aeruginosa (16.66%), and one venous leg ulcers was detected as sterile (8.33%). The number of different types of isolated bacterial species decreased significantly (P |
| Databáze: | OpenAIRE |
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