Changes in the content of human aortic glycoproteins and acid mucopolysaccharides in atherosclerosis
| Autor: | Raymond C. Read, Premanand V. Wagh, Bruce I. Roberts, Harold J. White |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Arteriosclerosis Uronic acid Glycosaminoglycan Residue (chemistry) chemistry.chemical_compound Sulfation medicine.artery Hyaluronic acid medicine Humans Aorta Aged Glycoproteins Glycosaminoglycans chemistry.chemical_classification Minerals Sulfates Chemistry Hexosamines Lipids Sialic acid Biochemistry Neuraminic Acids Collagen Cardiology and Cardiovascular Medicine Glycoprotein |
| Zdroj: | Atherosclerosis. 18:83-91 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(73)90119-6 |
| Popis: | The concentration of glycoproteins (GP) and acid mucopolysaccharides (AMPS) in apparently normal and atherosclerotic regions of human aortae taken at autopsy was determined both in terms of intimal surface area and dry, defatted, ash-free residue weight (DDAF). Variability due to age was excluded by choosing samples within the same age group. Total GP concentration increased significantly in atherosclerotic tissue as evidenced by increase in total neutral sugars, hexosamine and sialic acid both in terms of surface area and DDAF. The total uronic acid content was not altered. However, the ratio of sulfated:non-sulfated AMPS was significantly higher in atherosclerotic regions indicating that sulfated AMPS concentration is increased in atherosclerotic plaques at the expense of hyaluronic acid. These observations suggest that increased GP-concentration may have a functional role in the formation of atherosclerotic plaque. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|