Phaeochromocytoma: a ten-year survey
| Autor: | Sonia R. Salisbury, M. H. Tan, E. C. Abbott, K. C. Loh, A. H. Shlossberg |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adrenal Gland Neoplasm Adrenal Gland Neoplasms Adrenocorticotropic hormone Pheochromocytoma Urinalysis Asymptomatic Cushing syndrome chemistry.chemical_compound Recurrence medicine Palpitations Humans Vanillylmandelic acid Age of Onset Multiple endocrine neoplasia Child Aged Retrospective Studies Aged 80 and over business.industry Headache Arrhythmias Cardiac General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Treatment Outcome chemistry Hypertension Female medicine.symptom business |
| Zdroj: | QJM : monthly journal of the Association of Physicians. 90(1) |
| ISSN: | 1460-2725 |
| Popis: | We retrospectively evaluated our experience with phaeochromocytoma from January 1986 to December 1995. There were 18 patients with surgically-proven phaeochromocytoma: three males, 15 females, aged 12-81 years (mean 42 years) at diagnosis. Sixteen were hypertensive; only 6/18 presented with two or more of the classical triad of headaches, palpitations and diaphoresis. One patient presented with hypertensive crisis. Duration of symptoms prior to diagnosis was 2 weeks to 6 years, mean 16.4 months. Sixteen patients had adrenal tumours and two had extra-adrenal tumours or paragangliomas. One had bilateral adrenal tumours and two had a combination of both adrenal and extra-adrenal tumours. There were four familial cases: two had multiple endocrine neoplasia type IIA (MEN-IIA), one had neurofibromatosis type I (NF-I) and one von Hippel-Lindau (VHL) disease. One patient had Cushing's syndrome arising from ectopic production of adrenocorticotropic hormone (ACTH) by the phaeochromocytoma. Disease was recurrent in three patients. Pre-operative diagnosis was confirmed mainly by elevated urine vanillylmandelic acid (VMA) and/or catecholamine levels. Twelve patients had plasma catecholamine determinations: noradrenaline was elevated in all, adrenaline in six and dopamine in two. Pre-operative localization was by CT scan or MR imaging in all patients. At follow-up of 1-10 years (median 4.8 years), 15 patients were cured surgically while two were asymptomatic despite recurrence of disease. One patient with recurrent paragangliomas died post-operatively. |
| Databáze: | OpenAIRE |
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