Efficacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial
| Autor: | Robert P. Baughman, U Costabel, C.M. Fogarty, N. Vetter, Susan Flavin, Om P. Sharma, J.F. Donahue, R. Bonnet, Joachim Müller-Quernheim, Gerald S. Davis, Y. Wasfi, C Albera, P. Chanez, Daniel McNally, Michiel Thomeer, Milton D. Rossman, Herbert Patrick, Jan C. Grutters, Henk C. Hoogsteden, Gary W. Hunninghake, Kim Hung Lo, Henry Yeager, Ganesh Raghu, Laurent P. Nicod, Dominique Valeyre, Marc A. Judson, David S. Wilkes, Mani S. Kavuru, Lee S. Newman, Marjolein Drent, M. Kaye, Daniel A. Culver, F. Kanniess, Alvin S. Teirstein, Nadera J. Sweiss, Martin Brutsche, L. Tanoue, M. Mandel |
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| Přispěvatelé: | Pulmonologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Sarcoidosis Anti-Inflammatory Agents Placebo Placebo group Severity of Illness Index law.invention Pharmacotherapy Randomized controlled trial Double-Blind Method law Adrenal Cortex Hormones Internal medicine Severity of illness medicine Humans In patient business.industry Antibodies Monoclonal Middle Aged medicine.disease Infliximab Surgery Treatment Outcome Drug Therapy Combination Female business medicine.drug |
| Zdroj: | European Respiratory Journal, 31(6), 1189-96. European Respiratory Society |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | The aim of the present study was to investigate the efficacy of infliximab for the treatment of extrapulmonary sarcoidosis. A prospective, randomised, double-blind, placebo-controlled trial was conducted, with infliximab at 3 and 5 mg x kg(-1) body weight administered over 24 weeks. Extrapulmonary organ severity was determined by a novel severity tool (extrapulmonary physician organ severity tool; ePOST) with an adjustment for the number of organs involved (ePOSTadj). In total, 138 patients enrolled in the trial of infliximab versus placebo for the treatment of chronic corticosteroid-dependent pulmonary sarcoidosis. The baseline severity of extrapulmonary organ involvement, as measured by ePOST, was similar across treatment groups. After 24 weeks of drug-therapy study, the change from baseline to week 24 in ePOST was greater for the combined infliximab group compared with the placebo group. After adjustment for the number of extrapulmonary organs involved, the improvement in ePOSTadj observed in the combined infliximab group was also greater than that observed in placebo-treated patients, after 24 weeks of therapy. The improvements in ePOST and ePOSTadj were not maintained during a subsequent 24-week washout period. Infliximab may be beneficial compared with placebo in the treatment of extrapulmonary sarcoidosis in patients already receiving corticosteroids, as assessed by the severity tool described in the present study. |
| Databáze: | OpenAIRE |
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