Rab31 is expressed in neural progenitor cells and plays a role in their differentiation
| Autor: | Eyleen L. K. Goh, Bor Luen Tang, Christelle En Lin Chua |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Neurogenesis
Biophysics Biology Biochemistry Mice Neural Stem Cells Structural Biology otorhinolaryngologic diseases Genetics Animals Gene silencing Gene Silencing Molecular Biology Brain Cell Differentiation Cell Biology Anatomy Nestin Neural stem cell Cell biology stomatognathic diseases Gene Expression Regulation rab GTP-Binding Proteins Neural progenitor cell Differentiation Rab31 |
| Zdroj: | FEBS Letters. 588:3186-3194 |
| ISSN: | 1873-3468 0014-5793 |
| DOI: | 10.1016/j.febslet.2014.06.060 |
| Popis: | Rab31 is expressed in both GFAP- and nestin- positive fibres in regions of neurogenic potential in the adult mouse brain. To investigate the role of Rab31 in neural progenitor cells (NPCs), we cultured NPCs and found significant levels of Rab31 expression in these cells. Rab31 levels showed a sharp initial decrease and then reappeared gradually in a subpopulation of astrocytes when NPCs were induced to differentiate. Silencing of Rab31 hindered, while overexpression enhanced, the differentiation of NPCs to astrocytes. Our results suggest a previously unrecognised role for Rab31 in influencing the differentiation and fate of NPCs. |
| Databáze: | OpenAIRE |
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