The Effects of Sex Steroids on Plasma Levels of Marker Proteins of Endothelial Cell Functioning
| Autor: | T. Kooistra, H. Asscheman, P. J. M. van Kesteren, Ulrich M. Vischer, Mirian Lansink, J.J. Emeis, Louis Gooren, C.D.A. Stehouwer, G. J. Van Kamp |
|---|---|
| Přispěvatelé: | Gaubius Instituut TNO |
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Biology Tissue plasminogen activator chemistry.chemical_compound Internal medicine Ethinylestradiol Plasminogen Activator Inhibitor 1 von Willebrand Factor Blood plasma medicine Humans Endothelin-1 T-plasminogen activator Cyproterone acetate Hematology Endocrinology chemistry Tissue Plasminogen Activator Plasminogen activator inhibitor-1 Urinary Plasminogen Activator Cyproterone Biological Markers Female Steroids Endothelium Vascular Plasminogen activator Transsexualism medicine.drug |
| Zdroj: | Thrombosis and Haemostasis, 5, 79, 1029-1033 |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | SummaryWe studied thirteen male-to-female (M→F) and ten female-to-male (F→M) transsexuals who, for four months, received cross-sex treatment with, respectively, ethinylestradiol and cyproterone acetate, and with testosterone esters. We assessed the effects of treatment on plasma levels of tissue-type plasminogen activator (tPA), von Willebrand factor (vWF), vWF-propeptide (vWF:AgII) and bigendothelin-1 (big-ET-1), four proteins that are markers of endothelial cell functioning. We also measured urokinase-type PA (uPA) and plasminogen activator inhibitor-type 1 (PAI-1), which may not be endothelium-derived but share major clearance pathways with tPA.In M→F transsexuals, mean plasma levels of tPA (minus 4.4 ng/ml), big-ET-1 (minus 0.8 pg/ml), uPA (minus 0.5 ng/ml) and PAI-1 (minus 26 ng/ml) decreased (all Ps ≤0.02). The level of vWF increased (plus 24%; P = 0.005), while vWF:AgII did not change (P = 0.49).In F→M transsexuals, levels of big-ET-1 increased (plus 0.4 pg/ml; P = 0.02), while tPA, uPA and PAI-1 did not change (all Ps >0.25). In this group vWF decreased (minus 14%; P = 0.06), but vWF:AgII did not change (P = 0.38).Estrogens and androgens have clear effects on plasma levels of endothelial marker proteins. The mechanisms behind these effects are complex and appear to involve both altered secretion (big-ET-1) and processing and/or clearance (vWF and possibly tPA). Therefore, effects of hormones on the levels of endothelial marker proteins do not necessarily reflect changes in endothelial cell functioning, at least with regard to changes in vWF level associated with the oral administration of high doses of ethinylestradiol and cyproterone acetate to healthy men and the parenteral administration of testosterone to healthy women. |
| Databáze: | OpenAIRE |
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