Clustering of perinatal markers of birth asphyxia and outcome at age five years
| Autor: | A. Johnson, Karl W. Murphy, L. M. Clover, P. L. Yudkin |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Cardiotocography Developmental Disabilities Encephalopathy Acid-Base Imbalance Quadriplegia Cerebral palsy Cohort Studies Pregnancy London Medicine Humans Risk factor reproductive and urinary physiology Depression (differential diagnoses) Asphyxia Asphyxia Neonatorum business.industry Neonatal encephalopathy Infant Newborn Obstetrics and Gynecology Heart Rate Fetal medicine.disease Prognosis Child Preschool Cohort Apgar Score Apgar score Female medicine.symptom business |
| Zdroj: | British journal of obstetrics and gynaecology. 101(9) |
| ISSN: | 0306-5456 |
| Popis: | In a cohort of term infants with cerebral depression at delivery, to investigate the association of perinatal signs of birth asphyxia, particularly abnormal fetal heart rate patterns in labour, acidaemia, and serious neonatal encephalopathy, with neurodevelopmental outcome at age five years.Five year follow up study of a birth cohort.Regional maternity hospital.One hundred and eighty-four singleton infants with a 1 min Apgar scoreor = 3, born at term between January 1984 and September 1985.Neonatal death, cerebral palsy, and scores on a battery of neurodevelopmental tests at age five.Seven infants had a cluster of perinatal signs suggestive of birth asphyxia; all included serious neonatal encephalopathy. Three of these infants died neonatally, three had spastic quadriparesis with profound developmental delay, and one was unimpaired at the age of five. Among the remaining infants, no association was found between severely abnormal fetal heart rate patterns in labour and scores on neurodevelopmental tests, or between acid-base status at delivery and test scores.Birth asphyxia, identified by a cluster of abnormal perinatal signs, including serious neonatal encephalopathy, has a poor prognosis. If serious encephalopathy is not present, cerebral depression at birth preceded by abnormal fetal heart rate patterns in labour, or with acid-base derangement, is not predictive of later impairment. |
| Databáze: | OpenAIRE |
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