Estimating the Mechanical Properties of Retinal Tissue Using Contact Angle Measurements of a Spreading Droplet
| Autor: | Denis Greig, W. Hong Woon, M. D. Savage, Peter C. Twigg, Mark C. T. Wilson, Colin A. Grant |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Surface Properties Swine Microscopy Atomic Force Elastomer Retina Viscoelasticity Physics::Fluid Dynamics Contact angle Optics Electrochemistry Animals General Materials Science Composite material Elastic modulus Spectroscopy business.industry Drop (liquid) technology industry and agriculture Surfaces and Interfaces Nanoindentation Condensed Matter Physics Soft materials Elasticity Condensed Matter::Soft Condensed Matter Retinal tissue business |
| Zdroj: | Langmuir. 29:5080-5084 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la400650t |
| Popis: | When a drop of liquid is placed on the surface of a soft material, the surface deformation and the rate of spreading of the triple contact point is dependent on the mechanical properties of the substrate. This study seeks to use drop spreading behavior to infer the mechanical properties of soft biological materials. As an illustration of the value of this technique we have compared the spreading behavior of a liquid droplet on two viscoelastic, soft materials, namely, an elastomer and a low concentration agar gel. The ratio of the mechanical properties of these soft materials obtained in this way is confirmed by atomic force microscopy (AFM) nanoindentation. By comparing the spreading behavior of a liquid on the retina with that of the same liquid on each of two viscoelastic materials, we can then estimate the elastic moduli of the retina: an estimate that is extremely difficult to carry out using AFM. |
| Databáze: | OpenAIRE |
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