Expression of H2S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α

Autor: Jinjing Tian, Qian Chang, Shuxia Xuan, Li Tian, Ming Jiang, Yucui Teng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Blood Glucose
0301 basic medicine
Complications of pregnancy
endocrine system diseases
Article Subject
Endocrinology
Diabetes and Metabolism
Physiology
030204 cardiovascular system & hematology
Diseases of the endocrine glands. Clinical endocrinology
Umbilical vein
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Endocrinology
Downregulation and upregulation
Pregnancy
medicine
Humans
Insulin
Childbirth
Hydrogen Sulfide
Interleukin 6
Inflammation
biology
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
nutritional and metabolic diseases
Venous blood
Glucose Tolerance Test
Fetal Blood
RC648-665
medicine.disease
equipment and supplies
female genital diseases and pregnancy complications
Gestational diabetes
Diabetes
Gestational
030104 developmental biology
biology.protein
Female
business
Biomarkers
Research Article
Zdroj: Journal of Diabetes Research, Vol 2020 (2020)
Journal of Diabetes Research
ISSN: 2314-6745
DOI: 10.1155/2020/3085840
Popis: Background. Gestational diabetes mellitus (GDM) is a severe threat to the health of both mother and child. The pathogenesis of GDM remains unclear, although much research has found that the levels of hydrogen sulfide (H2S) play an important role in complications of pregnancy. Methods. We collected venous blood samples from parturient women and umbilical vein blood (UVB) and peripheral venous blood (PVB) samples one hour after childbirth in the control, GDM-, and GDM+ groups in order to determine the concentration of glucose and H2S in plasma; to measure levels of TNF-α, IL-1β, IL-6, TGF-β1, and ADP in parturient women and the UVB of newborns; and to find the correlation of H2S with regression. Results. We found that, with the elevation of glucose, the level of H2S was decreased in GDM pregnant women and newborns and the concentrations of IL-6 and TNF-α were upregulated. With regression, IL-6 and TNF-α concentrations were positively correlated with the level of blood glucose and negatively correlated with H2S concentration. Conclusion. This study shows that downregulation of H2S participates in the pathogenesis of GDM and is of great significance in understanding the difference of H2S between normal and GDM pregnant women and newborns. This study suggests that IL-6 and TNF-α are correlated with gestational diabetes mellitus. The current study expands the knowledge base regarding H2S and provides new avenues for exploring further the pathogenesis of GDM.
Databáze: OpenAIRE
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