Fetal Major Cardiac Defects and Placental Dysfunction at 11–13 Weeks’ Gestation
| Autor: | Taner Kasapoglu, Kypros H. Nicolaides, Dila Kasapoglu, Argyro Syngelaki, Ilaria Fantasia, Ranjit Akolekar |
|---|---|
| Přispěvatelé: | Fantasia, Ilaria, Kasapoglu, Dila, Kasapoglu, Taner, Syngelaki, Argyro, Akolekar, Ranjit, Nicolaides, Kypros H. |
| Rok vydání: | 2018 |
| Předmět: |
Placental growth factor
Placenta Diseases Pregnancy-associated plasma protein A 030204 cardiovascular system & hematology First trimester screening Fetal Distress 0302 clinical medicine Pregnancy Conotruncal defect Pregnancy-Associated Plasma Protein-A Ventricular outflow tract Prospective Studies 030212 general & internal medicine Uterine artery 030219 obstetrics & reproductive medicine Radiological and Ultrasound Technology Obstetrics Congenital heart defect Obstetrics and Gynecology General Medicine Uterine Artery Pulsatile Flow Pregnancy associated plasma protein-A Cardiology Gestation Female Uterine artery Doppler Perfusion Adult Heart Defects Congenital medicine.medical_specialty Gestational Age Ultrasonography Prenatal 03 medical and health sciences Fetal Heart Predictive Value of Tests medicine.artery Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Placenta Growth Factor Fetus business.industry United Kingdom Pregnancy Trimester First Reproductive Medicine Cardiac defects business Biomarkers |
| Zdroj: | Obstetrical & Gynecological Survey. 73:379-380 |
| ISSN: | 1533-9866 0029-7828 |
| DOI: | 10.1097/ogx.0000000000000584 |
| Popis: | OBJECTIVE To investigate the relationship between fetal major cardiac defects and markers of placental perfusion and function. METHODS This was a prospective screening study in singleton pregnancies at 11-13 weeks' gestation. Uterine artery pulsatility index (UtA-PI), serum pregnancy-associated plasma protein-A (PAPP-A) and placental growth factor (PlGF) were measured and the values were converted into multiples of the normal median (MoM). Median MoM values in fetuses with isolated major cardiac defects were compared with those in fetuses without major defects. RESULTS The 50 094 singleton pregnancies fulfilling the entry criteria included 49 898 pregnancies with normal cardiac anatomy and 196 (0.39%) with major congenital cardiac defects: 73 (37.2%) with conotruncal defects, 63 (32.1%) with left ventricular outflow tract defects and 60 (30.6%) with valvular defects. In the group with cardiac defects, compared with controls, there was lower median PAPP-A MoM (0.81 vs 1.00, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|