Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia
| Autor: | Michael Mane, Lucia Pirisi, Paul L. Hermonat, Sharon Bond, Rebecca B. Russell, Tsilya Gerasimova, Natalia A. Kokorina, Yong Liu, Ann L. Coker |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Sexually transmitted disease Oncology medicine.medical_specialty viruses Clinical Biochemistry Uterine Cervical Neoplasms medicine.disease_cause Lower risk Ambulatory Care Facilities Polymerase Chain Reaction Virus Pathology and Forensic Medicine Cohort Studies Risk Factors Internal medicine medicine Humans Risk factor Papillomaviridae Molecular Biology Adeno-associated virus Vaginal Smears biology business.industry Parvovirus virus diseases Odds ratio Dependovirus biology.organism_classification Virology female genital diseases and pregnancy complications Socioeconomic Factors Case-Control Studies DNA Viral Carcinoma Squamous Cell Female Viral disease business Papanicolaou Test |
| Zdroj: | Experimental and Molecular Pathology. 70:83-89 |
| ISSN: | 0014-4800 |
| DOI: | 10.1006/exmp.2000.2347 |
| Popis: | Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies. |
| Databáze: | OpenAIRE |
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