Detection of template binding to molecularly imprinted polymers by Raman microspectroscopy
| Autor: | Karsten Haupt, Keren Kantarovich, Ilana Bar, Levi A. Gheber, Anne-Sophie Belmont |
|---|---|
| Přispěvatelé: | Génie Enzymatique et Cellulaire (GEC), Université de Technologie de Compiègne (UTC)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Physics and Astronomy (miscellaneous) Chemistry Molecularly imprinted polymer Analytical chemistry 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Raman microspectroscopy symbols.namesake Polymerization symbols Molecule Enantiomer 0210 nano-technology Selectivity Raman spectroscopy |
| Zdroj: | Applied Physics Letters Applied Physics Letters, American Institute of Physics, 2009, 94, pp.194103 |
| ISSN: | 0003-6951 |
| Popis: | International audience; We report on sensitive and specific detection and quantification of a template in a molecularly imprinted polymer (MIP) using Raman microspectroscopy. The beta-blocking drug S-propranolol and its enantiomer, R-propranolol, were used as target molecules since the selectivity of this MIP is well established and serves as an appropriate validation standard. Specific peaks originating in the template were identified in the Raman spectrum, allowing quantification of bound target molecule. We demonstrate that label-free monitoring can be achieved from volumes as small as 1 µm3 of MIP, based on a single identifying peak. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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