Expression of NF-κB associated lncRNAs in schizophrenia

Autor:	Soudeh Ghafouri-Fard, Mohammad Taheri, Amin Safa, Elham Badrlou, Shahram Arsang-Jang, Arezou Sayad
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Oncology Adult Male medicine.medical_specialty lcsh:Medicine Article Pathogenesis chemistry.chemical_compound Text mining Internal medicine CEBPA medicine Humans lcsh:Science Aged Multidisciplinary Receiver operating characteristic business.industry lcsh:R NF-kappa B NF-κB Middle Aged medicine.disease Prognosis Peripheral Real-time polymerase chain reaction chemistry Gene Expression Regulation Schizophrenia Case-Control Studies Genetic markers Epigenetics Female RNA Long Noncoding lcsh:Q Gene expression business Biomarkers Follow-Up Studies
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports
ISSN:	2045-2322
Popis:	NF-κB signaling pathway has important roles in the regulation of growth and development of nervous system. This pathway has also been shown to participate in the pathogenesis of schizophrenia. Meanwhile, activity of NF-κB signaling pathway is regulated by several factors including non-coding RNAs (lncRNAs). In the current study, we evaluated expression of nine NF-κB-related lncRNAs namely DILC, ANRIL, PACER, CHAST, ADINR, DICER1-AS1, HNF1A-AS1, H19 and NKILA as well as two mRNA coding genes namely ATG5 and CEBPA in the peripheral blood of patients with schizophrenia compared with matched healthy subjects. Expressions of these genes were assessed by real time PCR technique. Expression of PACER was lower in patients with schizophrenia compared with controls (Posterior beta = − 0.684, P value = 0.049). On the other hand, expressions of CHAST, CEBPA, H19, HNF1A-AS1 and DICER1-AS1 were higher in patients compared with controls (Posterior beta = 0.39, P value = 0.005; Posterior beta = 0.844, P value CHAST, CEBPA, DICER1-AS1, H19 and HNF1A-AS1 in distinguishing between patients with schizophrenia and controls through depicting ROC curves. Based on the area under curve (AUC) values, CEBPA had the best diagnostic power (AUC = 0.948, P H19 (AUC = 0.815, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c9180ba233052789986ed1d772bfbc http://link.springer.com/article/10.1038/s41598-020-75333-w Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.