Expression of NF-κB associated lncRNAs in schizophrenia
Autor: | Soudeh Ghafouri-Fard, Mohammad Taheri, Amin Safa, Elham Badrlou, Shahram Arsang-Jang, Arezou Sayad |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Oncology
Adult Male medicine.medical_specialty lcsh:Medicine Article Pathogenesis chemistry.chemical_compound Text mining Internal medicine CEBPA medicine Humans lcsh:Science Aged Multidisciplinary Receiver operating characteristic business.industry lcsh:R NF-kappa B NF-κB Middle Aged medicine.disease Prognosis Peripheral Real-time polymerase chain reaction chemistry Gene Expression Regulation Schizophrenia Case-Control Studies Genetic markers Epigenetics Female RNA Long Noncoding lcsh:Q Gene expression business Biomarkers Follow-Up Studies |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | NF-κB signaling pathway has important roles in the regulation of growth and development of nervous system. This pathway has also been shown to participate in the pathogenesis of schizophrenia. Meanwhile, activity of NF-κB signaling pathway is regulated by several factors including non-coding RNAs (lncRNAs). In the current study, we evaluated expression of nine NF-κB-related lncRNAs namely DILC, ANRIL, PACER, CHAST, ADINR, DICER1-AS1, HNF1A-AS1, H19 and NKILA as well as two mRNA coding genes namely ATG5 and CEBPA in the peripheral blood of patients with schizophrenia compared with matched healthy subjects. Expressions of these genes were assessed by real time PCR technique. Expression of PACER was lower in patients with schizophrenia compared with controls (Posterior beta = − 0.684, P value = 0.049). On the other hand, expressions of CHAST, CEBPA, H19, HNF1A-AS1 and DICER1-AS1 were higher in patients compared with controls (Posterior beta = 0.39, P value = 0.005; Posterior beta = 0.844, P value CHAST, CEBPA, DICER1-AS1, H19 and HNF1A-AS1 in distinguishing between patients with schizophrenia and controls through depicting ROC curves. Based on the area under curve (AUC) values, CEBPA had the best diagnostic power (AUC = 0.948, P H19 (AUC = 0.815, P |
Databáze: | OpenAIRE |
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