Prediction of Neoadjuvant Chemotherapy Response in Osteosarcoma Using Convolutional Neural Network of Tumor Center 18F-FDG PET Images

Autor:	Sang-Keun Woo, Chang-Bae Kong, Ilhan Lim, Won Seok Song, Sang Moo Lim, Byung-Hyun Byun, Jin-Gyu Kim, Su Young Jeong, Byung-Chul Kim
Rok vydání:	2021
Předmět:	Medicine (General) medicine.diagnostic_test Receiver operating characteristic business.industry Deep learning chemotherapy response Clinical Biochemistry convolutional neural network Standardized uptake value 18F-FDG heterogeneity medicine.disease Convolutional neural network Article Random forest Support vector machine R5-920 machine learning Positron emission tomography osteosarcoma medicine Osteosarcoma Artificial intelligence business Nuclear medicine
Zdroj:	Diagnostics Volume 11 Issue 11 Diagnostics, Vol 11, Iss 1976, p 1976 (2021)
ISSN:	2075-4418
DOI:	10.3390/diagnostics11111976
Popis:	We compared the accuracy of prediction of the response to neoadjuvant chemotherapy (NAC) in osteosarcoma patients between machine learning approaches of whole tumor utilizing fluorine−18fluorodeoxyglucose (18F-FDG) uptake heterogeneity features and a convolutional neural network of the intratumor image region. In 105 patients with osteosarcoma, 18F-FDG positron emission tomography/computed tomography (PET/CT) images were acquired before (baseline PET0) and after NAC (PET1). Patients were divided into responders and non-responders about neoadjuvant chemotherapy. Quantitative 18F-FDG heterogeneity features were calculated using LIFEX version 4.0. Receiver operating characteristic (ROC) curve analysis of 18F-FDG uptake heterogeneity features was used to predict the response to NAC. Machine learning algorithms and 2-dimensional convolutional neural network (2D CNN) deep learning networks were estimated for predicting NAC response with the baseline PET0 images of the 105 patients. ML was performed using the entire tumor image. The accuracy of the 2D CNN prediction model was evaluated using total tumor slices, the center 20 slices, the center 10 slices, and center slice. A total number of 80 patients was used for k-fold validation by five groups with 16 patients. The CNN network test accuracy estimation was performed using 25 patients. The areas under the ROC curves (AUCs) for baseline PET maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV), and gray level size zone matrix (GLSZM) were 0.532, 0.507, 0.510, and 0.626, respectively. The texture features test accuracy of machine learning by random forest and support vector machine were 0.55 and 0. 54, respectively. The k-fold validation accuracy and validation accuracy were 0.968 ± 0.01 and 0.610 ± 0.04, respectively. The test accuracy of total tumor slices, the center 20 slices, center 10 slices, and center slices were 0.625, 0.616, 0.628, and 0.760, respectively. The prediction model for NAC response with baseline PET0 texture features machine learning estimated a poor outcome, but the 2D CNN network using 18F-FDG baseline PET0 images could predict the treatment response before prior chemotherapy in osteosarcoma. Additionally, using the 2D CNN prediction model using a tumor center slice of 18F-FDG PET images before NAC can help decide whether to perform NAC to treat osteosarcoma patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c401be9943d99abae22193e0928c31 https://doi.org/10.3390/diagnostics11111976 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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