Targeted delivery of TNF using NGR-TNF in combination with chemotherapy as an effective and tolerable strategy in a hepatocarcinoma patient

Autor:	Anna Spreafico, Gilda Rossoni, Elisa Roca, M. Giovannini, Giovanni Donadoni, Carmen Belli, Giovanni Citterio, Federico Caligaris Cappio, Angelo Corti, Vanesa Gregorc, Eugenio Villa, M. G. Vigano, Chiara Lazzari
Rok vydání:	2008
Předmět:	Tumor angiogenesis Chemotherapy business.industry Aminopeptidase N medicine.medical_treatment Hematology Pharmacology Targeted therapy Oncology NGR-hTNF Medicine Tumor necrosis factor alpha Doxorubicin Chemotherapeutic drugs business medicine.drug
Zdroj:	memo - Magazine of European Medical Oncology. 1:43-46
ISSN:	1865-5076 1865-5041
DOI:	10.1007/s12254-008-0011-8
Popis:	Targeted delivery of TNF to tumour vessels has been achieved by coupling this protein with the CNGRC peptide, an aminopeptidase N (CD13) ligand that targets the tumour neovasculature.The so-called NGR-TNF enhances the penetration of chemotherapeutic drugs in tumours and improves their efficacy. Here we describe a case of hepatocarcinoma which showed response to NGR-hTNF in combination with doxorubicin, clinically proving this promising strategy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c2a4958a26eea341e1030eccd33103 https://doi.org/10.1007/s12254-008-0011-8 Zobrazit plný text záznamu Full text from SpringerLink