Regulation of fibrinogen synthesis by plasmin-derived fragments of fibrinogen and fibrin: an indirect feedback pathway
| Autor: | Gerald M. Fuller, David G. Ritchie, Mark Adams, Bruce A. Levy |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Plasmin
Fibrinogen Fibrin Feedback Fibrin Fibrinogen Degradation Products chemistry.chemical_compound Biosynthesis Leukocytes medicine Animals Humans Secretion Fibrinolysin Cells Cultured Multidisciplinary Fibrin fragment D biology Chemistry Rats medicine.anatomical_structure Liver Biochemistry Hepatocyte biology.protein Research Article medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 79:1530-1534 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.79.5.1530 |
| Popis: | The effect of plasmin-derived fibrinogen fragments on the biosynthesis of fibrinogen was investigated in cultured monolayers of rat hepatocytes. Incubating the cells with several concentrations of either fibrinogen or fibrin fragment D or E had no effect on the synthesis and secretion of fibrinogen by these cells. However, if the fragments were incubated with isolated peripheral blood leukocytes, they caused these cells to secrete a factor that when added to the hepatocytes caused an increase in fibrinogen synthesis 4- to 6-fold over controls. Moreover, the hepatocyte-stimulating factor also affected the production of several other proteins produced by the hepatocyte. These results demonstrate that both fragments D and E can stimulate hepatic fibrinogen synthesis via an indirect leukocyte-mediated pathway. |
| Databáze: | OpenAIRE |
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