Immunogenicity of Leptospiral Vaccines Grown in Protein-free Medium
| Autor: | Ben Adler, S. Faine, W. L. Christopher |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Microbiology (medical)
Serotype animal diseases Guinea Pigs Biology Microbiology Bivalent (genetics) Antigen Formaldehyde medicine Animals Skin Tests Leptospira Immunogenicity General Medicine medicine.disease biology.organism_classification Virology Leptospirosis Cholera Culture Media Agglutinins Protein free Bacterial Vaccines Rabbits Leptospira interrogans |
| Zdroj: | Journal of Medical Microbiology. 15:493-501 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/00222615-15-4-493 |
| Popis: | SUMMARY. Leptospira interrogans serovars pomona and hardjo were adapted to grow in a chemically-defined, protein-free (PF) medium. Formolised monovalent vaccines of serovars pomona and hardjo and a bivalent mixture of the two were prepared from PF cultures. Live PF cultures and the vaccine preparations retained their agglutinating antigens and their immunogenicity when tested in rabbits and guineapigs. The vaccines were not pyrogenic and dermal reactions were slight. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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