Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer
| Autor: | Patricia Palmeira, Selma Freire de Carvalho da Cunha, Isabel Kinney Ferreira de Miranda Santos, José Joaquim Ribeiro da Rocha, Edson Zangiacomi Martinez, Sofia Miranda de Figueiredo Ribeiro, Camila Bitu Moreno Braga, Fernanda Maris Peria |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Placebo Gastroenterology Pneumococcal conjugate vaccine Pneumococcal Vaccines Double-Blind Method Internal medicine medicine Humans Prospective Studies Seroconversion Prospective cohort study Aged Chemotherapy Nutrition and Dietetics Vaccines Conjugate biology business.industry Vaccination Antibody titer Streptococcus Middle Aged Antibodies Bacterial Healthy Volunteers Zinc Sulfate Streptococcus pneumoniae Oncology Immunology Dietary Supplements biology.protein Female Antibody business Colorectal Neoplasms medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1532-7914 |
| Popis: | The aim of the study was to evaluate the effect of zinc supplementation on the antibody titer and the 23-valent pneumococcal seroconversion after vaccination in patients undergoing chemotherapy for colorectal cancer. The study included 25 patients undergoing postsurgery chemotherapy for colorectal adenocarcinoma (chemo group). Subjects were assessed in the perioperative period (prevaccination), before chemotherapy (4th wk) and after 3 cycles of chemotherapy (16th wk). Thirty-two healthy volunteers (control group) were included in the study. Participants received the 23-valent pneumococcal conjugate vaccine, and capsules containing zinc (Zn) sulfate (70 mg daily) or identical placebo capsules (containing wheat starch with no added Zn) for 16 wk and were randomly allocated on one of the following groups: chemo-Zn (n = 10), chemo-placebo (n = 15), control-Zn (n = 21), and control-placebo (n = 11). The antipneumococcal antibody titer against 6 polysaccharides was analyzed by ELISA and compared using linear mixed models. The seroconversion rate was compared using Fisher's exact test. An immune response to the vaccination against pneumococcus was observed in all participants. In the 16th wk, the polysaccharide 6 concentration was lower in the chemo-Zn group [2.96 (1.74-5.03) μg/mL] compared with the Chemo-Placebo group [10.75 (5.37-21.54) μg/mL] and the seroconversion rate was lower in the chemo-placebo (36%) compared with the control-placebo (85%) (P = 0.027). Zinc supplementation did not change the antibody titer after vaccination. However, the lower seroconversion rate observed in the chemo-placebo suggests an influence of zinc in the vaccinal protection. |
| Databáze: | OpenAIRE |
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