Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain
| Autor: | Daniel H. Lachance, James F. Howell, Aaron S. DeVries, Ermias D. Belay, Carlota Medus, Jennifer Adjemian, James J. Sejvar, W. Ian Lipkin, P. James B. Dyck, Scott E. Brueck, Stacy Holzbauer, Ruth Lynfield, Kirk E. Smith, Jennifer H. McQuiston, Julie R. Harris, Christine H. Lees, Richard Danila, Sergio Recuenco, Bryan F. Buss, Mady Hornig, John D. Gibbins, Catherine Lexau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Veterinary medicine Neurological Disorders/Peripheral Neuropathies Swine lcsh:Medicine fluids and secretions 0302 clinical medicine Epidemiology Research article lcsh:Science Public Health and Epidemiology/Occupational and Industrial Medicine 0303 health sciences Multidisciplinary food and beverages Brain Middle Aged 3. Good health Occupational Diseases Female Occupational exposure Abattoirs Research Article Adult medicine.medical_specialty Minnesota Polyradiculoneuropathy Public Health and Epidemiology Immunology/Autoimmunity Disease cluster Neurological Disorders Autoimmune Diseases 03 medical and health sciences Immune system Internal medicine Occupational Exposure medicine Animals Humans 030304 developmental biology business.industry Compressed Air lcsh:R technology industry and agriculture Case-control study medicine.disease Case-Control Studies lcsh:Q Public Health and Epidemiology/Epidemiology business 030217 neurology & neurosurgery Porcine brain |
| Zdroj: | PLoS ONE, Vol 5, Iss 3, p e9782 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head-table). An investigation was initiated to determine risk factors for illness. Methods and Results Symptoms of the reported patients were unlike previously described occupational associated illnesses. A case-control study was conducted at Plant A. A case was defined as evidence of symptoms of peripheral neuropathy and compatible electrodiagnostic testing in a pork abattoir worker. Two control groups were used - randomly selected non-ill warm-room workers (n = 49), and all non-ill head-table workers (n = 56). Consenting cases and controls were interviewed and blood and throat swabs were collected. The 26 largest U.S. pork abattoirs were surveyed to identify additional cases. Fifteen cases were identified at Plant A; illness onsets occurred during May 2004–November 2007. Median age was 32 years (range, 21–55 years). Cases were more likely than warm-room controls to have ever worked at the head-table (adjusted odds ratio [AOR], 6.6; 95% confidence interval [CI], 1.6–26.7), removed brains or removed muscle from the backs of heads (AOR, 10.3; 95% CI, 1.5–68.5), and worked within 0–10 feet of the brain removal operation (AOR, 9.9; 95% CI, 1.2–80.0). Associations remained when comparing head-table cases and head-table controls. Workers removed brains by using compressed air that liquefied brain and generated aerosolized droplets, exposing themselves and nearby workers. Eight additional cases were identified in the only two other abattoirs using this technique. The three abattoirs that used this technique have stopped brain removal, and no new cases have been reported after 24 months of follow up. Cases compared to controls had higher median interferon-gamma (IFNγ) levels (21.7 pg/ml; vs 14.8 pg/ml, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|